《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (11): 917-918.

• 基础研究 • 上一篇    下一篇

久强脑立清对急性高血压大鼠重要器官的保护作用

郝文宇; 杨楠; 张彦东; 陈志高; 左萍萍   

  1. 中国医学科学院基础医学研究所 北京市 100005
  • 收稿日期:2005-10-08 出版日期:2005-11-25 发布日期:2005-11-25

Protective effects of Jiuqiang Naoliqing on vital organs in acute hypertension rats

HAO Wen-yu, YANG Nan, ZHANG Yan-dong,et al   

  1. Department of Pharmacology, School of Basic Medicine, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100005, China
  • Received:2005-10-08 Published:2005-11-25 Online:2005-11-25

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摘要： 目的探讨久强脑立清(JNQ)对急性高血压大鼠重要器官脑、肾、心的影响。方法采用左旋硝基精氨酸(L-NNA)制做急性高血压大鼠模型,然后给高、中、低剂量JNQ和阳性对照药硝苯地平,观察心功能指标及重要器官HE染色的变化。结果急性高血压大鼠血压两周后比对照升高36%,脑、肾、心均可见病理性改变,但各组大鼠的心率、心电图和血压未见明显差异。经JNQ治疗的大鼠心肌收缩力和心肌耗氧量明显下降,左室内压上升速度明显减慢;脑、心、肾病理改变有不同程度改善。结论尽管JNQ对急性高血压大鼠的心率、血压无明显影响,但可降低心肌耗氧,改善心功能指标,对重要器官脑、肾、心的病变有较明显的保护作用。

关键词: 久强脑立清, 高血压, 脑, 肾, 心, 病理, 大鼠

Abstract: ObjectiveTo investigate the effects of Jiuqiang Naoliqing(JNQ) on the morphology of the vital organs(the brain,kidney and heart) in acute hypertension rats.MethodsThe model was established by L-NG-nitro arginine(L-NNA),which can inhibit the synthesis of nitric oxide(NO).Affected animals were administrated with high,medium or low dose of JNQ while nifedipine was used as the positive control.Effects on cardiac function and morphology of the vital organs were investigated.Results2 weeks after the establishment of the model,the affected rats had a 36% higher blood pressure compared with the control group.The acute hypertension rats showed significant pathologic changed in the brain,kidney and heart,while there was no obvious difference in the heart rate,electrocardiaogram,and blood pressure between the administrated groups.After treatment with JNQ,the contraction force and the oxygen extraction of the myocardiocytes were significantly reduced and the increasing velocity of the left ventricular pressure was decreased.The brain,kidney and heart showed improvement in pathology analysis to different levels.ConclusionAlthough it has no obvious effects on the heart rate and blood pressure in acute hypertension rats,JNQ can decrease the oxygen extraction in myocardiocytes and can obviously alleviate brains,kidneys and hearts pathologic changes.

Key words: Jiuqiang Naoliqing, hypertension, brain, kidney, heart, pathology, rat