《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (11): 924-926.

• 基础研究 • 上一篇    下一篇

α-玉米赤霉醇对实验性高脂血症兔的血脂代谢及血液流变学的影响

赵小元; 左萍萍; 段金虹; 陆媛; 张仪华; 程锦轩; 吴云清; 鲁杰; 孙仁宇; 戴顺龄   

  1. 1.首都儿科研究所 北京市 100020;2.中国医学科学院,中国协和医科大学基础医学院 北京市 100005
  • 收稿日期:2005-10-08 出版日期:2005-11-25 发布日期:2005-11-25

Influence of α-Zearalanol on lipometabolism and hemorheology in experimental hyperlipidemia rabbits

ZHAO Xiao-yuan, ZUO Ping-ping, DUAN Jin-hong,et al   

  1. Capital Institute of Pediatrics, Beijing ,100020, China
  • Received:2005-10-08 Published:2005-11-25 Online:2005-11-25

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摘要： 目的本研究是探讨α-玉米赤霉醇(-αZAL)在抗动脉粥样硬化(AS)作用中,对血脂代谢及血液流变学的影响。方法44只成熟未孕新西兰大耳白雌兔,分为5组,A组为正常对照组,B组为假手术组,C组为切除卵巢组,D组为切除卵巢并给予17β雌二醇(17βE2)阳性对照药组,E组为切除卵巢并给予-αZAL组。喂胆固醇(CHO)前与12周后,分别测定血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)含量。还分别测定了全血黏度、血浆黏度、红细胞聚集指数(AIRC)及纤维蛋白原及血小板聚集率。结果B、D、E组TC、TG、LDL-C明显低于C组(P<0.05);全血黏度、血浆黏度、AIRC和血小板聚集率也明显低于C组(P<0.05)。结论-αZAL可能通过干预血脂代谢,调节全血黏度、血浆黏度和AIRC及血小板聚集率,改善血管功能。

关键词: 植物雌激素, 高脂血症, 脂质代谢, 血液流变学, α-玉米赤霉醇(-αZAL)

Abstract: ObjectiveTo investigate the effect of α-Zearalanol(α-ZAL) on lipometabolism and hemorheology in ovariectomized(OVX) hyperlipidemia rabbits.Methods44 adult virgin female rabbits were divided into 5 groups,group A: normal control;group B: sham+CHO;group C: OVX+CHO;group D: OVX+CHO+17βE_2;group E: OVX+CHO+α-ZAL.Cholesterol(CHO) was fed to rabbits for 12 weeks.Before and after feeding CHO,the serum lipid(TC,TG,LDL-C,HDL-C) were measured;Blood viscosity,plasma viscosity,aggregation index of RBC(AIRC) and fibrinogen were also assayed respectively.ResultsThe serum levels of TC,TG and LDL-C in group B and E were significantly decreased compared with those in group C(P<0.05);the level of blood viscosity,plasma viscosity and AIRC platelet aggregation rate in group D and E were also significantly decreased compared with those in group C(P<0.05).Conclusionα-ZAL can improve vascular function through the adjustment of lipometabolism and hemorheology.

Key words: phytoestrogen, hyperlipidemia, lipometabolism, hemorheology, α-Zearalanol