《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (11): 940-941.

• 临床研究 • 上一篇    下一篇

尿转化生长因子β1对老年人早期糖尿病肾病的诊断意义

姚坚坚; 钱芸娟; 林琦; 李东风   

  1. 广东省人民医院老年病研究所肾内科 广东广州市 510080
  • 收稿日期:2005-08-01 出版日期:2005-11-25 发布日期:2005-11-25

Urinalysis of transforming growth factor-β1 in old patients with diabetic nephropathy

YAO Jian-jian,QIAN Yun-juan,LIN Qi,et al   

  1. Department of Nephrology,Institute of Geriatrics,Guangdong People's Hospital,GuangZhou 510080, Guangdong, China
  • Received:2005-08-01 Published:2005-11-25 Online:2005-11-25

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摘要： 目的探讨检测尿转化生长因子-β1(TGF-β1)对诊断老年人早期糖尿病肾病的临床价值。方法检测53例老年2型糖尿病患者及27名正常老年人的尿TGF-β1、尿微量白蛋白、尿α1-微球蛋白、β2-微球蛋白、空腹血糖及糖化血红蛋白并进行分析比较。结果正常白蛋白尿DM组尿TGF-β1为(21.2±7.32)ng/mmolCr,微量白蛋白尿DM组尿TGF-β1为(58.79±25.93)ng/mmolCr,两组间有非常显著性差异(P<0.01),均明显高于正常老年对照组的(7.79±3.58)ng/mmolCr(均P<0.01)。相关分析表明,尿TGF-β1与尿微量白蛋白(r=0.5415)、尿α1-微球蛋白(r=0.6282)、尿β2-微球蛋白(r=0.3248)呈显著正相关(均P<0.01),与糖化血红蛋白无相关性(r=0.2304,P>0.05)。结论尿TGF-β1测定似可作为老年2型糖尿病肾病早期诊断的一项敏感可靠的指标。

关键词: 糖尿病, 并发症, 糖尿病肾病, 转化生长因子-β1

Abstract: ObjectiveTo search detecting urine transforming growth factor-β1(TGF-β1) of type 2 diabetes mellitus(DM) in diagnosing early diabetic nephropathy in old patients.MethodsTGF-β1,microalbumin,microglobulin α1 and microglobulin β2 in urine from 53 cases of old type 2 diabetics and 27 cases of normal controls were detected.ResultsTGF-β1 was(21.2±7.32) ng/mmolCr in diabetics whose urine albumin were normal and was(58.79±25.93) ng/mmolCr in diabetics whose urine microalbumin was abnormal(P<0.01).Both were significantly higher than that of the normal control which was(7.79±3.58) ng/mmolCr(P<0.01).TGF-β1 was direct remarkably correlative with microablumin(r=0.5415),microglobulin α1(r=0.6282) and microglobulin β2(r=0.3248)(P<0.01 respectively),but was nothing with glycohemoglobin(r=0.2304,P>0.05).ConclusionTGF-β1 detection may be used as a sensitive and reliable guideline to diagnose early diabetic nephropathy in old diabetics.

Key words: diabetes mellitus, complication, diabetic nephropathy, transforming growth factor-β1