《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (01): 66-67.

• 临床研究 • 上一篇    下一篇

脑电双频谱指数在ICU镇静剂使用中的监测作用

宋青; 周飞虎; 潘亮; 王秀英   

  1. 解放军总医院外科重症监护科 北京市 100853
  • 收稿日期:2005-09-26 出版日期:2006-01-25 发布日期:2006-01-25

Application of bispectral index during sedation in the patients in ICU

SONG Qing, ZHOU Fei-hu, PAN Liang, et al   

  1. Department of Surgical Intensive Care Unit, General Hospital of PLA, Beijing 100853, China
  • Received:2005-09-26 Published:2006-01-25 Online:2006-01-25

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摘要： 目的探讨脑电双频谱指数(BIS值)在监测ICU患者镇静剂使用中的价值。方法入住ICU患者60例,随机分为3组,每组患者持续微量泵泵入异丙酚和咪唑安定,用药量根据BIS值随时调整。Ⅰ组患者使BIS值维持在75～85,Ⅱ组患者使BIS值维持在65～75,Ⅲ组患者使BIS值维持在55～65,并注意维持患者血流动力学稳定。结果用异丙酚和咪唑安定镇静前、后平均动脉压(MAP)和心率(HR)在Ⅰ和Ⅱ组患者间无明显变化(P>0.05),而在Ⅲ组患者则有所降低(P<0.05);Ⅰ组、Ⅱ组、Ⅲ组患者Ramsay评分平均分别为2.2、3.4、4.6;异丙酚用量分别为:(9.54±2.43)μg/kg·min、(12.69±3.12)μg/kg·min、(14.18±2.91)μg/kg·min,咪唑安定用量分别为:(0.23±0.09)μg/kg·min、(0.25±0.07)μg/kg·min、(0.28±0.11)μg/kg·min。结论脑电双频谱指数监测能很好反映患者的镇静深度。应根据ICU不同患者病情要求来取得不同的镇静效果。

关键词: 脑电双频谱指数, 异丙酚, 咪唑安定, 镇静, 重症监护室(ICU)

Abstract: ObjectiveTo evaluate the value of bispectral index(BIS) monitoring during sedation in the ICU.Methods60 patients in ICU were randomly divided into three groups. By transfusing propofol and midazolam with injecting pump, the BIS of groups Ⅰ,Ⅱ and Ⅲ were controlled within 75～85, 65～75 and 55～65, respectively. ResultsCompared with the pre-sedation, there was no remarkable change in the patients of groups Ⅰ and Ⅱ after sedation(P>0.05)while there was remarkable change in the patients of group Ⅲ(P<0.05).The average score of Ramsay in groups Ⅰ, Ⅱ and Ⅲ were 2.2, 3.4 and 4.6 while the dose of propofol were (9.54±2.43) μg/kg·min, (12.69±3.12) μg/kg·min, (14.18±2.91) μg/kg·min and the dose of midazolam were (0.23±0.09) μg/kg·min, (0.25±0.07) μg/kg·min, (0.28±0.11) μg/kg·min, respectively.ConclusionThe application of BIS can make good judgement in the sedation, which showed different choices to different needs to obtain optimistical sedation effect.

Key words: bispectral index, propofol, midazolam, sedation, intensive care unit(ICU)