《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (03): 207-209.

• 基础研究 • 上一篇    下一篇

行为学训练对大鼠海马梗死后齿状回区神经生长因子表达的影响

江山1a; 李玲2; 袁华1a; 潘惠娟3; 王冰1b   

  1. 1.西安第四军医大学西京医院,a.康复理疗科;b.中医科 陕西西安 710032;2.解放军总医院第一附属医院康复理疗科 北京市 100037;3.上海东方医院理疗科 上海市 200120
  • 收稿日期:2005-10-25 出版日期:2006-03-25 发布日期:2006-03-25

Effect of Behavior Training on the Expression of Neural Growth Factor in the Dentate Gyrus in Rats with Left Lateral Hippocampal Infarction

JIANG Shan, LI Ling, YUAN Hua, et al   

  1. Department of Physiotherapy and Rehabilitation, Xijing Hospital,Fourth Military Medical University, Xi'an 710032, Shaanxi, China
  • Received:2005-10-25 Published:2006-03-25 Online:2006-03-25

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摘要： 目的研究行为学训练对大鼠海马梗死后齿状回区神经生长因子(NGF)表达的影响。方法将102只SD大鼠随机分为训练3 d、7d、14 d、21 d、28 d、35 d、42 d、49 d组;制动3 d、7 d、14 d、21 d、28 d、35 d、42 d、49 d组及正常对照组,每组6只。采用光化学法造成大鼠左侧海马区梗死,训练组于造模1 d后开始给予水迷宫训练,制动组于造模1 d后开始给予制动,观察不同时间点各组大鼠海马齿状回区NGF的表达。结果正常大鼠海马的齿状回区NGF有一定的表达,造模后,训练组及制动组齿状回区NGF的表达均有所增高,但训练组的表达要高于制动组。结论行为学训练可增加NGF在海马齿状回区的表达,可能会促进大鼠海马梗死后脑自身的修复能力,促进神经功能的重建。

关键词: 脑梗死, 海马齿状回, 神经生长因子(NGF), 大鼠, 水迷宫

Abstract: ObjectiveTo study the effect of behavior training on the expression of neural growth factor(NGF) in the dentate gyrus(DG) in rats with left lateral hippocampal infarction.Methods102 SD rats were randomized into fore-training,3 d,7 d,14 d,21 d,28 d,35 d,42 d,49 d training groups,fore-immobilization, 3 d、7 d,14 d,21 d,28 d,35 d,42 d,49 d immobilization groups and control group.Behavior training and immobilization were performed at 1st day after the infarction.Immunohistochemistry was used to detect the expression of NGF in the DG at different points of time.ResultsThe expression of NGF is certain in the normal DG of rats.The expression of NGF increased after infarction.However,the expression of NGF had obviously increased in fore-training groups compared with that in fore-immobilization groups.ConclusionBehavior training can accelerate the expression of NGF in the DG of rats with left hippocampal infarction.

Key words: cerebral infarction, dentate gyrus, neural growth factor(NGF), rat, water maze