《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (03): 222-223.

• 基础研究 • 上一篇    下一篇

消化道肿瘤组织芯片中BAG-1的表达及意义分析

林雨冬1; 师建国1; 闫庆国1; 王明元2; 王星2   

  1. 1.第四军医大学西京医院病理科 陕西西安市 710032;2.南京军区福州总医院95临床部 福建莆田市 351100
  • 收稿日期:2006-01-10 出版日期:2006-03-25 发布日期:2006-03-25

Expression and Significance of Apoptosis Related Gene BAG-1 in Digestive Tract Cancer by Tissue Microarray

LIN Yu-dong, SHI Jian-guo, YAN Qing-guo, et al   

  1. Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi, China
  • Received:2006-01-10 Published:2006-03-25 Online:2006-03-25

PDF (PC)

被引次数

5

摘要： 目的检测抗凋亡基因BAG-1在多种消化道肿瘤中的表达,并讨论其意义。方法利用组织芯片,采用免疫组化DA-KO Envision法检测食道癌、胃癌、直肠癌及正常组织中BAG-1的表达。结果食道癌、胃癌及直肠癌组织中BAG-1的表达比其对应的正常组织为高(P<0.01)。结论BAG-1在消化道肿瘤组织中表达高于正常组织,提示BAG-1表达可能与消化道恶性肿瘤的发生有关。

关键词: BAG-1, 免疫组织化学, 消化道肿瘤, 组织芯片

Abstract: ObjectiveTo detect BAG1 expressions in digestive tract cancer by tissue microarray and to evaluate its clinical significance.MethodsTissue microarray of digestive tract cancer and normal tissues were analyzed by DAKO Envision system immunohistochemical staining for apoptosis related gene BAG-1 expression.ResultsThe positive rate of BAG-1 expression among esophagus cancer,gastric cancer and rectal cancer were higher than that of normal tissues respectively(P<0.01).ConclusionThere is an overexpression of BAG-1 in digestive tract cancer,which suggest that apoptosis related gene BAG-1 may be related to these cancer.

Key words: BAG-1, immunohistochemistry, digestive tract cancer, tissue microarray