《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (05): 381-382.

• 专题 • 上一篇    下一篇

树突状细胞肿瘤疫苗联合免疫佐剂治疗小鼠乳腺癌的初步探讨

贾鑫1a; 李荣1b; 徐迎新1b; 李力1b   

  1. 1.中国人民解放军总医院,a.血管外科;b.普通外科研究所 北京市 100853
  • 收稿日期:2006-03-21 出版日期:2006-05-25 发布日期:2006-05-25

Effect of Dendritic Cell Vaccine Coupled with Immune Adjuvant on the Inhibition of Murine Breast Carcinoma

JIAXin,LIRong,XU Ying-xin,et al   

  1. Vascular Surgery Department, General Hospital of PLA, Beijing 100853, China
  • Received:2006-03-21 Published:2006-05-25 Online:2006-05-25

PDF (PC)

被引次数

6

摘要： 目的研究免疫佐剂绿脓杆菌菌毛是否可以提高树突状细胞肿瘤疫苗的治疗作用。方法使用EMT6乳腺癌株种植BALB/c小鼠建立肿瘤模型,分成4组,次日在小鼠皮下分别注射生理盐水、免疫佐剂、树突状细胞肿瘤疫苗和树突状细胞肿瘤疫苗+免疫佐剂。定期测量肿瘤大小,21d后处死小鼠称量肿瘤重量。结果注射树突状细胞肿瘤疫苗+免疫佐剂组肿瘤生长得到了明显抑制,与空白对照组比较,P=0.001,与单纯应用树突状细胞肿瘤疫苗组比较,P=0.047。结论绿脓杆菌菌毛作为免疫佐剂,可以和树突状细胞肿瘤疫苗发生协同作用,提高对小鼠乳腺癌的治疗效果。

关键词: 树突状细胞, 免疫佐剂, 乳腺癌

Abstract: ObjectiveTo investigate whether immune adjuvant can enhance the immunity of dendritic cell vaccine against murine breast cancer. Methods4 groups of mice with tumor are injected saline, immume adjuvant, dendritic cell (DC) vaccine and DC vaccine coupled with immune vaccine, respectively. Tumor volume and weight are measured 21 d later.ResultsThe tumor size in the DC vaccine coupled with immune vaccine group was significantly small compared with control group (P=0.001) and the DC vaccine group (P=0.047).ConclusionImmune adjuvant can enhance the immunity of dendritic cell vaccine against murine breast cancer.

Key words: dendritic cell, immune adjuvant, breast carcinoma