《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (06): 467-468.

• 专题 • 上一篇    下一篇

灯盏花素对家兔缺血预适应心肌保护作用的影响

赵国安1; 张三强2; 陈志刚1; 殷国田1; 孙海燕1   

  1. 1.新乡医学院第三附属医院 河南新乡市 453003;2.新乡医学院第二附属医院 河南新乡市 453000
  • 收稿日期:2006-04-19 出版日期:2006-06-25 发布日期:2006-06-25

Effect of Breviscapine on Rabbit's Cardiac Muscles after Ischemic Preconditioning

ZHAO Guo-an, ZHANG San-qiang, CHEN Zhi-gang, et al   

  1. The Third Affiliated Hospital of Xinxiang Medical College, Xinxiang 453003, Henan, China
  • Received:2006-04-19 Published:2006-06-25 Online:2006-06-25

PDF (PC)

被引次数

21

摘要： 目的探讨灯盏花素(Bre)对家兔缺血预适应(IP)心肌保护作用的影响。方法32只新西兰大耳白兔通过左冠状动脉左室支穿以丝线造成心肌缺血再灌注(R),随机分为心肌缺血再灌注(I/R)组、Bre+I/R组、IP组和Bre+IP组,测定各组动物的心肌梗死面积及心肌酶、血浆内皮素(ET)和一氧化氮(NO)含量变化。结果Bre和IP可减少心肌梗死范围,降低肌酸激酶、乳酸脱氢酶和ET含量,增加NO含量,联合应用Bre+IP可进一步加强心肌保护作用。结论Bre可以对缺血心肌产生保护作用,联合应用Bre可以加强IP对心肌的保护作用。

关键词: 心肌缺血再灌注, 缺血预适应, 灯盏花素, 一氧化氮, 内皮素

Abstract: ObjectiveTo explore the effect of the Breviscapine (Bre) on rabbit's cardiac muscles after ischemic preconditioning (IP).MethodsThe myocardial ischemic reperfusion model was made with 32 New Zealand white rabbits by silk thread passed around the left circumflex coronary artery and the apex. Model animals were randomly divided into four groups: myocardial ischemia-reperfusion (I/R) group, Bre+I/R group, IP group and Bre+IP group. The changes of the endothelin (ET), nitrous oxide (NO) and the enzymes of the cardiac muscle were measured, and the areas of myocardium infarction were analyzed.ResultsBre and IP could decrease the content of ET, the enzymes of the cardiac muscle and myocardial infarction area; increase the content of the NO. Bre+IP could strengthen the role of protecting the ischemic myocardial cells.ConclusionThe Bre can protect the ischemic cardiac muscle. The Bre+IP can strengthen the protective effect of the IP.

Key words: myocardial ischemic reperfusion, ischemic preconditioning, Breviscapine, nitrous oxide, endothelin