《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (08): 716-718.

• 临床研究 • 上一篇    下一篇

癫痫和抗癫痫药对事件相关电位N270的影响

孙伟1,2; 王玉平2; 王薇薇1; 王荫华1; 吴逊1   

  1. 1.北京大学第一医院神经内科,北京市 100034;2.首都医科大学附属宣武医院神经内科,北京市 100053
  • 收稿日期:2006-05-10 出版日期:2006-08-01 发布日期:2006-08-01

Effect of Epilepsy and Anti-epileptic Drug on Event-related Potential N270

SUN Wei, WANG Yu-ping, WANG Wei-wei, et al   

  1. The Department of Neurology, the First Hospital of Peking University, Beijing 100034, China
  • Received:2006-05-10 Published:2006-08-01 Online:2006-08-01

PDF (PC)

摘要： 目的探讨癫痫患者事件相关电位N270的特征及其反映患者认知功能的价值。方法35例癫痫患者根据服药情况分为卡马西平组、丙戊酸钠组和未用药组,另设健康志愿者作为对照组。所有受试者均接受简易智力量表问卷测试,同时记录事件相关电位。结果3组患者的N270差异曲线峰潜伏期长于对照组,波幅低于对照组,其中丙戊酸钠组患者的峰波幅低于其他3组(P<0.05)。患者组P300峰波幅低于对照组,丙戊酸钠组的波幅低于其他3组(P<0.05)。结论癫痫患者存在认知功能损害;抗癫痫药丙戊酸钠对癫痫患者处理冲突能力的损害较卡马西平明显;N270检测癫痫患者早期认知损害的敏感度高于P300。

关键词: 癫痫, 卡马西平, 丙戊酸钠, N270, P300

Abstract: ObjectiveTo investigate the characteristics of event-related potential (ERP) N270 and the value of ERP N270 to detect the cognitive function in patients with epilepsy.MethodsThirty-five epileptics were divided into carbamazepine (CBZ) group (n=10), valproate (VPA) group (n=10) and no treatment group (n=15) according to drugs they took, and other 10 healthy subjects were selected as the control group. All subjects were evaluated by Mini-Mental State Examination (MMSE), and ERP was recorded at same time.ResultsAll patients in three groups showed a delayed and smaller N270 than the control group ( P<0.01). VPA group had the lowest N270 amplitude. The amplitude of P300 elicited in the match condition decreased in the VPA group compared with other three groups ( P<0.05), but latency of the VPA group was not different from other three groups.ConclusionCognitive impairment is present in epilepsy patients, and the effect of anti-epileptic drug VPA on ability of patients to process conflict is more evidence than CBZ. The sensitivity of N270 to detect early cognitive impairment in epileptics is higher than P300.

Key words: epilepsy, carbamazepine, valproate, N270, P300