《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (09): 809-810.

• 临床研究 • 上一篇    下一篇

开颅术中应用地塞米松对血糖影响的研究

王德祥; 孟岚; 韩如泉; 王保国   

  1. 首都医科大学附属北京天坛医院麻醉科,北京市 100050
  • 收稿日期:2006-03-27 出版日期:2006-09-01 发布日期:2006-09-01

Effect of Low Dose Dexamethasone on Blood Glucose Concentration in Patients Undergoing Craniotomy

WANG De-xiang, MENG Lan, HAN Ru-quan, et al   

  1. Department of Anesthesiology, Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing 100050, China
  • Received:2006-03-27 Published:2006-09-01 Online:2006-09-01

PDF (PC)

被引次数

3

摘要： 目的评价神经外科术中静脉单次应用小剂量地塞米松对血糖的影响。方法择期行幕上颅内肿瘤切除术患者20例,ASAI～II级,随机双盲分为两组:地塞米松组(D组,n=10)和生理盐水组(S组,n=10),分别于麻醉诱导前给予地塞米松10mg(D组)或生理盐水2ml(S组)。分别在注药前、注药后60min、120min、180min、240min和300min取动脉血进行血糖分析。结果应用地塞米松120min后血糖水平较基础值显著升高并持续至用药后300min(F=3.133,P<0.05),而生理盐水组术中血糖无显著变化。地塞米松组与生理盐水组相比,在用药后180min(t=3.033,P<0.01)、240min(t=3.838,P<0.01)、300min(t=2.873,P<0.05)动脉血糖增高。结论神经外科患者围术期应慎重使用糖皮质激素,并应加强血糖监测及控制。

关键词: 开颅术, 糖皮质激素, 高糖血症

Abstract: ObjectiveTo evaluate the effect of low dose of dexamethasone on the blood glucose concentration in patients undergoing craniotomy. Methods20 consecutive patients undergoing craniotomy without a preexisting metabolic disorder were prospectively randomized into 1 of 2 groups: Dexamethasone (group D, n=10) and Normal Saline (group S, n=10), who were given dexamethasone 10 mg intravenous bolus or a saline placebo preoperatively. Arterial glucose concentrations were measured immediately before and after treatment and hourly for 5 hours intraoperatively. ResultsThe arterial glucose concentration in group D increased significantly(F=3.133,P<0.05), while those in group S keep stable. Compared with group S, arterial glucose concentration in group D increased significantly 180 min after dosing(P<0.01). ConclusionIf dexamethasone is used during craniotomy, perioperative blood glucose level should be carefully monitored and controled.

Key words: craniotomy, corticosteroid, hyperglycemia