《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (10): 867-870.

• 综述 • 上一篇    下一篇

脑缺血炎症反应与星形胶质细胞的关系

颜因1,2 综述; 罗勇1,2 审校   

  1. 1.重庆医科大学附属第一医院神经内科,重庆市 400016;2.重庆市神经病学重点实验室,重庆市 400016
  • 收稿日期:2006-07-03 出版日期:2006-10-01 发布日期:2006-10-01

Relationship Between Cerebral Ischemia-induced Inflammation and Astroglia (review)

YAN Yin, LUO Yong   

  1. The Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
  • Received:2006-07-03 Published:2006-10-01 Online:2006-10-01

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摘要： 脑缺血后星形胶质细胞作为中枢神经系统第一个受损的细胞,出现肥大、增殖,并合成表达多种炎症介质,启动免疫级联反应。星形胶质细胞产生的炎症介质共同作用于中枢神经系统,损伤和保护脑组织机制并存。了解星形胶质细胞及其表达的炎症介质,对寻找减轻脑缺血后炎症反应损伤的新途径具有重要意义。

关键词: 脑缺血, 星形胶质细胞, 炎症介质, 炎症反应, 综述

Abstract: Astroglia is the first cell type in the central nervous system to encounter insult after brain ischemia. Then ischemia stimulates hypertrophic and proliferative changes in astroglia and induces it produce inflammatory factors involved in the initiation of immunologic cascade. The expression of these cytokines which interact in the central nervous system can both damage and protect the brain tissue. Therefore, it is important to study astroglia and cytokines in order to find a new way to reduce inflammation insults after brain ischemia.

Key words: cerebral ischemia, astroglia, inflammatory factor, inflammatory reaction, review