《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (12): 1067-1069.

• 综述 • 上一篇    下一篇

干细胞可塑性争议

梁丽玲; 杨庭树   

  1. 北京军区总医院内分泌科,北京市 100700
  • 收稿日期:2006-05-17 出版日期:2006-12-01 发布日期:2006-12-01

Debates on Plasticity of Stem Ccells (review)

LIANG Li-ling, YANG Ting-shu   

  1. The Department of Endocrinology, the General Hospital of Beijing Army, Beijing 100700, China
  • Received:2006-05-17 Published:2006-12-01 Online:2006-12-01

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摘要： 传统观点认为,成体组织中的干细胞具有有限分化潜能,只能分化产生其所在组织中的某个或某些特定的细胞。近年来随着研究的深入,人们发现干细胞的分化潜能远比先前认为的更为广泛,即干细胞具有可塑性或发生横向分化的潜能。但是,许多研究者对这一观点提出了质疑。笔者对有关干细胞可塑性的不同观点作一概述,讨论在目前公认的动物模型上观察到的干细胞可塑性现象。

关键词: 干细胞, 可塑性, 横向分化, 综述

Abstract: Traditionally, stem cells in adult tissues were believed to be restricted in their differentiation potential and limited to generate the types of cell present in the tissue in which the stem cell resides. Recently, however, many studies indicate that stem cells may display a broader differentiation potential, termed plasticity or transdifferentiation, than what was previously thought. But the validity of this understanding has been challenged by some investigators. In this review, the authors present some standpoints on stem cell plasticity and discuss some phenomena of stem cell plasticity observed on animal models those have been generally accepted currently.

Key words: stem cells, plasticity, transdifferentiation, review