《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (12): 1088-1089.

• 临床研究 • 上一篇    下一篇

A型肉毒毒素治疗脑卒中后不同状态上肢痉挛的疗效

崔利华1,2; 芦海涛1,2   

  1. 1.首都医科大学康复医学院神经病学系,北京市 100068;2.北京博爱医院神经康复科,北京市 100068
  • 收稿日期:2006-08-30 出版日期:2006-12-01 发布日期:2006-12-01

Effect of Injection of Botulinum Toxin Type A on Spasticity of Upper Extremity with Different Functional Status after Stroke

CUI Li-hua, LU Hai-tao   

  1. The Department of Neurology, the Faculty of Rehabilitation, Capital Medical University, Beijing 100068, China
  • Received:2006-08-30 Published:2006-12-01 Online:2006-12-01

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摘要： 目的观察国产A型肉毒毒素(CBTX-A)注射治疗脑卒中后不同功能状态的上肢痉挛的疗效。方法根据上肢功能情况将32例脑卒中患者分为功能较好组(n=13)和功能较差组(n=19),均给予国产A型肉毒毒素肱二头肌局部注射和康复治疗,分别在治疗前和治疗后8周采用主动关节活动度、改良Ashworth评分、Fugl-Meyer评定(FMA)及Mot-FIM-上肢评分法评定患者的上肢功能。结果治疗8周后,两组患者的主动关节活动范围和FMA评分均比治疗前提高(P<0.05),但功能较好组功能性改善的程度优于功能较差组(P<0.05);改良Ashworth评分降低程度两组间的差异无显著性意义(P>0.05);Mot-FIM-上肢评分均比治疗前提高(P<0.05),但两组间的差异亦无显著性意义(P>0.05)。结论肱二头肌局部注射A型肉毒毒素对脑卒中后上肢伸肘肌功能较好的患者的疗效优于伸肘肌功能较差的患者。

关键词: A型肉毒毒素, 脑卒中, 上肢痉挛, 康复

Abstract: Objective To observe the effect of botulinum toxin A (BTX-A) on spasticity of upper extremity with different functional status after stroke.Methods 32 post-stroke patents with upper extremity spasticity were divided into the good function group (n=13) and poor function group (n=19) according to the function of upper extremity. All patients in two groups were treated with injection of domestic BTX-A at the biceps brachii and rehabilitation therapy. The efficacy was assessed with rang of motion, Modified Ashowrth Scale (MAS), Fugl-Meyer Assessment (FMA) and Mot-FIM upper extremity before and 8-week after treatment.Results After treatment, the rang of motion and FMA scores of patients in two groups improved ( P<0.05), but the good function group was superior to the poor function group; the scores of MAS of two groups were not different ( P>0.05); the scores of Mot-FIM upper extremity of the patients in two groups increased ( P<0.05), and there was no significant difference between two groups ( P>0.05).Conclusion The effect of BTX-A injection at the biceps brachii on post-stroke patients with good function of upper extremity is superior to the patients with poor function of upper extremity.

Key words: botulinum toxin A, stroke, upper extremity spasticity, rehabilitation