《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (12): 1100-1101.

• 临床研究 • 上一篇    下一篇

慢性肺疾病患者血浆内皮素1、一氧化氮、血气与血液黏度关系的研究

李金兰; 周义乾; 张素荣; 袁晓梅; 郭悦鹏; 于维霞; 齐咏; 张志强   

  1. 新乡医学院一附院呼吸科,河南卫辉市 453100
  • 收稿日期:2006-05-11 出版日期:2006-12-01 发布日期:2006-12-01

Research of Plasma Endothelin-1,Nitrousoxide,Blood Gas,and Blood Viscosity in Patients with Chronic Pulmonary Disease

LI Jin-lan, ZHOU Yi-qian, ZHANG Su-rong, et al   

  1. The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100,Henan, China
  • Received:2006-05-11 Published:2006-12-01 Online:2006-12-01

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被引次数

6

摘要： 目的探讨慢性支气管炎(慢支)、慢性阻塞性肺气肿(肺气肿)、慢性肺源性心脏病(肺心病)患者不同时期血浆内皮素1(ET-1)、一氧化氮(NO)、动脉血气、血液流变学的变化及其关系。方法检测慢支、肺气肿、肺心病等三组患者和健康对照组(均为40例)的血浆ET-1和NO,以及全血黏度(bη)、红细胞压积(Hct)及集聚指数(AI),另抽取动脉血检测血气,并与正常组对照。结果肺气肿、肺心病患者血浆ET-1增高,血气、血液流变学指标异常,且由肺气肿发展到肺心病时,ET-1逐渐增高,血氧分压(PaO2)逐渐降低,二氧化碳分压(PaCO2)逐渐增高;从慢支发展为肺气肿、肺心病时,全血黏度、Hct、AI逐渐增高,NO逐渐降低。结论慢支发展为肺气肿、肺心病时,血浆ET-1、PaCO2逐渐增高,NO、pH、PaO2逐渐降低,血液红细胞增多、全血黏度和AI增高的情况逐渐加重。

关键词: 慢性支气管炎, 肺气肿, 肺心病, 血浆内皮素1, 一氧化氮, 血气分析, 血液黏度

Abstract: Objective To explore the changes of plasma endothelin-1 (ET-1), nitrousoxide (NO), blood gas analysis, and blood rheology in patients with chronic bronchitis (CB), pulmonary emphysema (PE) and pulmonary heart disease (PHD) at different periods.Methods The plasma ET-1, NO, blood viscosity, hematocrit (Hct) and aggregation index (AI) of patients in groups of CB, PE and PHD, and the subjects of the control group were tested and compared. Blood gas analysis of subjects in four groups also performed and compared. Each group had 40 cases.Results In PE and PHD patients, the ET-1 level was higher, the indexes of blood gas analysis and blood rheology were abnormal. When PE developed into PHD, the ET-1 and PaCO2 tended to increase, PaO2 tended to decrease. When CB developed into PE and PHD, the blood viscosity, pressure volume and AI tended to increase, but NO tended to decrease.Conclusion When CB developed into PE or PHD, ET-1, PaCO2 tend to increase and NO, pH, PaO2 tend to decrease; increased red blood cells, blood viscosity and AI become severe.

Key words: chronic bronchitis, pulmonary emphysema, pulmonary heart disease, endothelin-1, nitrousoxide, blood gas analysis, blood viscosity