《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (01): 35-36.

• 专题　药物康复 • 上一篇    下一篇

加味补阳还五汤对次声暴露下小鼠学习记忆能力的影响

范建中1; 杨俊峰1; 陈景藻2; 谭晓明1   

  1. 1.南方医科大学南方医院康复医学科,广东广州市 510515;2.第四军医大学西京医院康复医学科,陕西西安市 710032
  • 收稿日期:2006-09-07 出版日期:2007-01-01 发布日期:2007-01-01

Protection by Jiawei Buyang Huanwu Decoction from the Harm of Infrasound (16 Hz,130 dB)in Mice

FAN Jian-zhong, YANG Jun-feng, CHEN Jing-zao,etal   

  1. Departmentof Rehabilitation Medicine, NanfangHospital, NanfangMedicine University, Guan gzhou 510515, Guangdong, China
  • Received:2006-09-07 Published:2007-01-01 Online:2007-01-01

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摘要： 目的观察加味补阳还五汤对16Hz(8Hz),130dB次声暴露下小鼠学习记忆能力的影响。方法将学习记忆能力相近的80只BALB/c小鼠分为16Hz组和8Hz组,其中每组再分为空白对照组、次声对照组以及次声加用药组(根据用药剂量的不同又分高、中、低剂量组),处理14d后测试其学习记忆能力的变化。结果次声对照组的学习记忆能力降低(P<0.05),16Hz用药组较次声对照组的逃逸时间明显缩短(P<0.01),8Hz用药组较次声对照组的逃逸时间无显著性差异,各剂量组之间未见显著性差异。结论16Hz(8Hz),130dB次声暴露14d(2h/d)可引起小鼠学习记忆能力的下降。加味补阳还五汤可以提高16Hz次声暴露后小鼠的学习记忆能力。

关键词: 次声, 加味补阳还五汤, 学习记忆, 小鼠

Abstract: ObjectiveTo study the effects of Jiawei Buyang Huanwu Decoction on learning and memory abilities of mice exposed to 130 dB infrasound (16 Hz). Methods80 BALB/c mice were divided into blank-control group, infrasound-control group, infrasound and drug-treated group (it was divided into 3 sub-groups according to dose). Learning and memory abilities were measured 14 d later. ResultsCompared with blank-control group, learning and memory abilities decreased (P<0.05) in infrasound-control group. Compared with infrasound-control group, learning and memory abilities increased(P<0.01) in infrasound and drug-treated group. Conclusion16 Hz,130 dB infrasound could damage learning and memory abilities. Jiawei Buyang Huanwu Decoction could protect mice from learning and memory harm exposed to the infrasound.

Key words: infrasound, Jiawei Buyang Huanwu Decoction, learning and memory, mice