《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (01): 39-41.

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血小板源性生长因子与组织修复

闫国和; 艾国平; 邹仲敏; 粟永萍   

  1. 第三军医大学预防医学院全军复合伤研究所 创伤、烧伤与复合伤国家重点实验室,重庆市 400038
  • 收稿日期:2006-10-08 出版日期:2007-01-01 发布日期:2007-01-01

Platelet-derived Growth Factors and Tissue Repair

YAN Guo-he,AI Guo-ping,ZOU Zhong-min,et al   

  1. State Key Laboratory of Trauma,Burns and Combined Injury,Institute of Combined Injury,College of Preventive Medicine,Third Military Medical University,Chongqing 400038,China
  • Received:2006-10-08 Published:2007-01-01 Online:2007-01-01

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被引次数

45

摘要： 血小板源性生长因子(PDGFs)属糖蛋白二聚体(分子量27000～35000)家族,它向间质源细胞施以有力的促有丝分裂和趋化活性活动。PDGFs在胚胎发育、细胞分化和对组织损伤的反应等过程中具有许多极为重要的作用。它是创面愈合过程中较早出现的生长因子之一。特别是对一些慢性难愈性伤口,如糖尿病溃疡、慢性静脉性溃疡、压疮、放射性溃疡等PDGFs均有明显促进愈合作用。

关键词: 血小板源性生长因子(PDGFs), 组织修复, 基因治疗, 综述

Abstract: Platelet-derived growth factors (PDGFs) are a member of family of glycoprotein dimers (Mr 27000～35000) that exert potent mitogenic and chemotactic activities toward cells of mesenchymal origin. The PDGFs possess a myriad of critical roles in embryonic development,cellular differentiation and response to tissue damage. It is one of the growth factors,which appear early during the process of wound healing. Especially,PDGFs can effectively promote the healing of some chronic refractory wounds,such as diabetes mellitus ulcer,chronic venous ulcer,bedsore,radioactivity ulcer,etc..

Key words: platelet-derived growth factors (PDGFs), tissue repair, gene therapy, review