《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (01): 56-58.

• 综述 • 上一篇    下一篇

骨钙素与脊髓损伤

郑樱1,2; 纪树荣1,2; 周红俊1,2; 刘根林1,2; 郝春霞1,2; 潘立东1,2   

  1. 1.首都医科大学康复医学院,北京市 100068;2.北京博爱医院,北京市 100068
  • 收稿日期:2006-10-23 出版日期:2007-01-01 发布日期:2007-01-01

Characteristics of Osteocalcin after Spinal Cord Injury (review)

ZHENG Ying, JI Shu-rong, ZHOU Hong-jun, et al   

  1. Faculty of Rehabilitation, Capital Medical University, Beijing 100068, China
  • Received:2006-10-23 Published:2007-01-01 Online:2007-01-01

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摘要： 骨钙素是骨代谢的生化标志物之一,是成骨细胞分泌的骨蛋白,其水平与成骨细胞活性成正相关,可以反映骨形成与骨转化的情况。脊髓损伤后骨代谢初步显示是以破骨性骨吸收增强为主要特点,不伴有或伴有轻度的骨形成增强,表现为高转换性骨代谢。通过测定骨钙素及其他骨代谢的生化标志物可以在一定程度上了解脊髓损伤后骨代谢的状况,反映其发展变化的特点,并评价各种治疗及预防脊髓损伤后骨质疏松方法的效果。

关键词: 骨钙素, 脊髓损伤, 骨质疏松, 综述

Abstract: Osteocalcin is one of the biochemical markers of bone metabolism, produced by mature osteoblasts. It has been shown that serum osteocalcin is a marker of osteoblastic activity, and the levels reflect the rate of bone formation and bone turnover. Bone metabolism after spinal cord injury (SCI) initially reflects a disproportion between highly bone resorption and almost normal or lightly elevated bone formation, indicating an increase in bone turnover. Osteocalcin and other biochemical markers may be helpful to know the bone metabolism after SCI and to evaluate the effect of all kinds of methods in treating and preventing osteoporosis after SCI.

Key words: osteocalcin, spinal cord injury, osteoporosis, review