《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (01): 8-9.

• 专题　药物康复 • 上一篇    下一篇

运动功能的药物康复

朱镛连   

  1. 北京博爱医院神经内科,北京市 100068
  • 收稿日期:2006-10-11 出版日期:2007-01-01 发布日期:2007-01-01

Drug Rehabilitation for Motor Function after Brain Injury

ZHU Yong-lian   

  1. Department of Neurology, BeijingCharity Hospital,Beijing 100068, China
  • Received:2006-10-11 Published:2007-01-01 Online:2007-01-01

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摘要： 运动功能是人类参与社会活动的主要功能之一。不幸的是,无论是中枢还是周围神经病损,常见的症状是瘫痪。虽然到目前还没有一种药物能使瘫痪迅速、完全、滿意的恢复,但从上世纪中叶起,科学家们即对一些药物,如苯丙胺等进行了运动功能方面的试验,并取得了一些成果。虽然该药物目前被权威机构不推荐使用于治疗运动功能,然而由于研究苯丙胺作用而发现一些其他药物也有类似的促进运动功能恢复的作用,如氟西汀、丙炔苯丙胺、左旋多巴等。同时还发现在脑卒中急性期对运动功能有害的一些药物,如氟哌啶醇、苯妥英、哌唑嗪等。

关键词: 脑损伤, 运动功能障碍, 药物康复

Abstract: Motor function is the main function of human being takes place the social activities in the world. Unfortunately, regardless of either CNS or PNS injury, the outcome usually is paralysis. Up to date there is still no drug may restore the function of paralyzed limbs rapidly, completely and satisfactorily. However, the scientist have used drugs to enhance motor function recovery after brain injury and got some effects since the mid of past century, e.g. the amphetamine. The function of amphetamine, notwithstanding was denied by Veterans Affairs/Department of Defense Clinical Practice Guideline for the Management of Adult Stroke Rehabilitation Care in 2005, however, there were other reports concerning with same purpose study, that may facilitate the recovery of motor function, e.g. Fluoxetine, Selegiline, L-dopa and so on. In the meantime, there also found some drugs with opposite effect and slowing the functional recovery, e.g., Haloperidol, Prazosin, Phenytoin and so forth.

Key words: brain injury, motor function impaired, drug rehabilitation