《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (02): 151-153.

• 基础研究 • 上一篇    下一篇

冰片对丙戊酸钠透过血脑屏障的影响

陈瑞玲; 赵志刚; 张星虎; 刘凤琴; 李东梅   

  1. 首都医科大学附属北京天坛医院,北京市 100050
  • 收稿日期:2007-01-15 出版日期:2007-02-01 发布日期:2007-02-01

Effect of Borneol on Sodium Valproate Passing Blood-brain Barrier

CHEN Rui-ling, ZHAO Zhi-gang, ZHANG Xing-hu, et al   

  1. Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, China
  • Received:2007-01-15 Published:2007-02-01 Online:2007-02-01

PDF (PC)

摘要： 目的探讨冰片对丙戊酸钠在家兔体内透过血脑屏障的影响。方法12只家兔随机分为对照组和冰片组,每组6只。两组动物均静脉滴注丙戊酸钠达稳态,之后冰片组予冰片灌胃给药。采用荧光偏振免疫分析法检测家兔血浆和脑脊液丙戊酸钠的浓度,计算药代动力学参数。结果与对照组相比,冰片组家兔脑脊液平均药物浓度升高,曲线下面积增加(P<0.05),稳态脑脊液药物浓度出现峰值时间为6h,脑血浓度比亦升高(P<0.05),但血药浓度并未升高。结论冰片可提高血脑屏障对丙戊酸钠的通透性,但对血药浓度影响较小。

关键词: 冰片, 丙戊酸钠, 血脑屏障

Abstract: ObjectiveTo observe the effect of berneol on sodium valproate passing the blood-brain barrier in rabbits.Methods12 rabbits were randomly divided into the control group and borneol group with 6 animals in each group. All animals were treated with intravenous infusion of sodium valproate until steady state; while the rabbits of the borneol group received oral borneol. The sodium valproate concentration in serum and cerebrospinal fluid (CSF) was determined. The pharmacokinetics parameters obtained from two groups were analyzed. ResultsIn the berneol group, the mean drug concentration in CSF and area under curve increased significantly ( P<0.05) compared with those of the control group, and the time of drug reaching the peak concentration in CSF was 6 hours, the ratio of CSF to plasma also increased significantly ( P<0.05), while the blood concentration not increased.ConclusionBorneol can enhance the permeability of blood-brain barrier to sodium valproate, but has small influence on blood concentration.

Key words: borneol, sodium valproate, blood-brain barrier