《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (03): 258-260.

• 综述 • 上一篇    下一篇

周围神经趋化性再生的细胞和分子生物学机制

王冠军; 卢世璧; 孙明学   

  1. 解放军总医院骨科研究所,北京市 100853
  • 收稿日期:2006-12-20 出版日期:2007-03-01 发布日期:2007-03-01

Cellular and Molecular Biological Mechanisms of Peripheral Nerve Selective Regeneration (review)

WANG Guan-jun, LU Shi-bi,SUN Ming-xu   

  1. Institute of Orthopaedics, General Hospital of PLA, Beijing 100853, China
  • Received:2006-12-20 Published:2007-03-01 Online:2007-03-01

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摘要： 周围神经损伤的治疗是临床上的难题。以往研究主要集中在神经损伤后断端缺损的桥接修复和提高神经的再生速度,但实际上功能的恢复更取决于再生轴索能否精确地长入原先支配的靶器官。因此,充分理解神经趋化性再生的细胞和分子生物学基础,在治疗中运用神经再生趋化性理论,对促进神经功能恢复具有重要的意义。本文就周围神经再生趋化性理论及其细胞和分子生物学机制的研究进展作一综述。

关键词: 周围神经, 神经再生, 神经趋化性, 综述

Abstract: The management of peripheral nerve injury is a tough problem clinically.Intensive studies in the past were focused on the bridging of nerve defects and the improvement of regeneration rate.But actually the clinical results of functional recovery after peripheral nerve lesion is mainly decided by the accurate regeneration of axons to their original target tissues and structures.Therefore,better clinical results could be obtained by a greater understanding of the cellular and molecular biology of selective nerve regeneration and the application of this theory clinically.This paper summarized recent studies on the cellular and molecular biology mechanisms of peripheral nerve selective regeneration.

Key words: peripheral nerve, nervous regeneration, chemotropism, review