《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (03): 281-282.

• 临床研究 • 上一篇    下一篇

肝气郁结证患者正电子发射脑功能成像研究

刘子旺1; 王玉来1; 尹岭2; 单保慈3; 王爱成1; 赵永烈1; 滕晶4; 秦绍林1   

  1. 1.北京中医药大学东方医院,北京市 100078;2.中国人民解放军总医院神经信息中心,北京市 100853;3.中国科学院高能物理研究所,北京市 100039;4.山东中医药大学附属医院,济南市 250011
  • 收稿日期:2006-12-22 出版日期:2007-03-01 发布日期:2007-03-01

Findings in Positron Emission Tomography of Brain in Patients with Syndrome of Stagnation of Liver-Qi

LIUZi-wang,WANG Yu-lai,YIN Ling, et al   

  1. Dongfang Hospital,Peking University of Chinese Medicine, Beijing 100078,China
  • Received:2006-12-22 Published:2007-03-01 Online:2007-03-01

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被引次数

13

摘要： 目的利用正电子发射成像(PET)脑功能成像技术探讨肝气郁结证在特定脑区功能的改变。方法将10例肝气郁结证患者(肝郁组)和20例正常健康志愿者(对照组)进行18F-脱氧葡萄糖(18F-FDG)PET成像扫描,应用SPM图像分析软件对扫描数据进行组间t检验分析,获得肝气郁结证引起的脑内葡萄糖代谢变化的区域。结果肝郁组葡萄糖利用率减低脑区(P<0.001)有右侧顶叶(中央后回,BA1/2)、颞叶(颞中回,BA37)、额叶(额中回,BA9/10)。葡萄糖利用率增高的脑区(P<0.001)有右侧额叶(额上回、额下回,BA22/28/44)、右侧扣带回、双侧中脑、小脑。结论肝气郁结证可引起特定脑区的功能改变。

关键词: 肝气郁结, 正电子发射计算机断层显像, 脑功能

Abstract: Objective To explore the characteristics of patients with stagnation of liver-qi syndrome using brain functional imaging techniques.Methods10 patients with stagnation of liver-qi syndrome and 20 normal persons whom paired by sex and age were scanned with positron emission tomography(PET).Data analysis was carried out using SPM in MATLAB software.ResultsCompared with normal,some cerebral areas of the patients with stagnation of liver-qi syndrome showed glucose metabolism letdown(P<0.001),including right parietal lobe(postcentral gyrus,BA1/2),temporal lobe(middle temporal gyrus,BA37),frontal lobe(middle frontal gyrus,BA9/10)etc.,while some cerebral areas showed glucose metabolism heighten(P<0.001)including right frontal lobe(superior frontal gyrus,inferior fontal gyrus,BA22/28/44),right cingulated gyrus,double midbrain and cerebella,etc.ConclusionThe function of some cerebral areas can be changed undergoing stagnation of liver-qi syndrome.

Key words: syndrome of stagnation of liver-qi, positron emission tomography, cerebral function