《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (05): 419-420.

• 基础研究 • 上一篇    下一篇

参龙汤对D-半乳糖诱导衰老大鼠学习记忆功能的影响

陈利平; 韩志涛; 王发渭; 刘毅   

  1. 解放军总医院中医科 解放军总医院老年病研究所,北京市 100853
  • 收稿日期:2006-12-15 出版日期:2007-05-01 发布日期:2007-05-01

Effect of Shenlongtang on Learning and Memory of Aging Rats Induced with D-Glalactose

CHEN Li-ping, HAN Zhi-tao, WANG Fa-wei, et al   

  1. Department of Chinese Medicine, Institute of Geratology, General Hospital of PLA, Beijing 100853, China
  • Received:2006-12-15 Published:2007-05-01 Online:2007-05-01

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摘要： 目的探讨参龙汤对D-半乳糖拟衰老大鼠学习记忆能力的影响。方法Wistar大鼠40只随机分为对照组、参龙汤1组(大剂量)、参龙汤2组(中剂量)、参龙汤3组(小剂量)、模型组。采用D-半乳糖诱导的脑老化大鼠动物模型,用通道式水迷宫测定大鼠学习记忆能力的变化;测定药物处理后各组大鼠脑组织超氧化物歧化酶(SOD)活性、丙二醛(MDA)浓度的变化。结果与正常对照组相比,模型组大鼠游泳时间延长、游泳正确次数降低(均P<0.05)。应用参龙汤大剂量处理6周后,大鼠的游泳时间降低,正确次数增加(P<0.05);同时大剂量参龙汤组还能提高D-半乳糖诱导的脑老化大鼠脑组织中SOD的活性,降低丙二醛浓度(P<0.05)。结论参龙汤能改善D-半乳糖诱导的脑老化大鼠学习记忆能力,提高脑组织中SOD的活性,降低丙二醛的浓度。

关键词: 衰老, D-半乳糖, 参龙汤, 中药, 学习, 记忆, 超氧化物歧化酶(SOD), 丙二醛(MDA), 大鼠

Abstract: Objective To investigate the effect of Shenlongtang on the function of learning and memory of aging rats induced with D-glalactose. Methods 40 Wistar rats were dividied into control group, model group, treating group 1 (large dosage), treating group 2 (medial dosage), treating group 3 (lower dosage). The aging models were induced with D-galactose. The memory function was tested with passageway water maze. The activity of superoxide dismutase (SOD) and content of malodialdehyde (MDA) was measured. Results In the D-galactose model rats, the swimming time was prolonged significantly, and the correct number was decreased significantly compared with normal group (P<0.05). After Six weeks treating with Shenlongtang, the swimming time significantly shortened and the correct number increased significantly in large dosage group compared with the model group (P<0.05). The activity of SOD increased and the content of MDA decreased in large dosage group compared with that in the model group (P<0.05).Conclusion Shenlongtang can improve the learning and memory function of aging rats induced with D-glalactose and resist lipid peroxide in brain tissue.

Key words: senescence, D-glalactose, Shenlongtang, Chinese medicine, learning, memory, superoxide dismutase (SOD), malodialdehyde (MDA), rats