《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (05): 421-422.

• 基础研究 • 上一篇    下一篇

国产水蛭肽对兔抗凝疗效观察

李珊; 盖鲁粤   

  1. 解放军总医院,北京市 100853
  • 收稿日期:2007-02-06 出版日期:2007-05-01 发布日期:2007-05-01

Anticoagulant Activity of Hirulog in Rabbits in Vivo

LI Shan, GAI Lu-yue   

  1. General Hospital of PLA, Beijing 100853, China
  • Received:2007-02-06 Published:2007-05-01 Online:2007-05-01

PDF (PC)

被引次数

27

摘要： 目的研究国产水蛭肽在兔体内的抗凝活性,为水蛭肽临床应用提供实验依据。方法兔静脉注射水蛭肽前及后心脏采血,应用血凝仪测定凝血酶时间(TT)、凝血酶原时间(PT)、活化的部分凝血活酶时间(APTT),并观察其量效和时效关系及与肝素的抗凝疗效比较。结果水蛭肽能明显延长TT、PT、APTT,且呈剂量依赖性,其抗凝作用随时间延长而下降,作用持续时间约60min,水蛭肽抗凝疗效至少与肝素相同。结论水蛭肽具有明显抗凝作用,量效关系明确,不亚于现有抗凝药肝素。

关键词: 水蛭肽, 抗凝, 兔

Abstract: Objective To study the anticoagulant activity of hirulog. Methods Rabbits blood samples were collected before and after injecting hirulog. Thrombin clot time (TT), prothrombin time (PT) and activated partial thromboplastin time (APTT) were measured to investigate the dose-effect and time-effect relationship of hirulog and compared the efficacy with heparin. Results TT, PT and APTT of rabbits blood samples were prolonged remarkably by hirulog, and the action duration was about 60 min, that was similar to heparin. Conclusion Hirulog showed obvious anticoagulant effects with clear dose-effect relationship.

Key words: hirulog, anticoagulant, rabbits