《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (05): 477-478.

• 临床研究 • 上一篇    下一篇

利培酮在无精神病性症状抑郁症中的应用

钱建军; 何炳福; 石永扬; 高赛男; 金海龙   

  1. 绍兴市第七人民医院心理科,浙江绍兴市 312
  • 收稿日期:2006-12-19 出版日期:2007-05-01 发布日期:2007-05-01

Application of Risperidone in Depression without Psychotic Symptoms

QIAN Jian-jun, HE Bing-fu, SHI Yong-yang, et al   

  1. Department of Psychology, Shaoxing Seventh People's Hospital, Shaoxing 312000, Zhejiang, China
  • Received:2006-12-19 Published:2007-05-01 Online:2007-05-01

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摘要： 目的评价利培酮在治疗无精神病性症状抑郁症中的地位。方法206例患者随机分为利培酮联合氟西汀组、利培酮组和氟西汀组治疗8周,于治疗前、治疗2周末、4周末、6周末和8周末分别测评汉密尔顿抑郁量表(HAMD)和副反应量表(TESS)。结果满8周后,联用组HAMD减分率大于氟西汀组(P<0.05),氟西汀组大于利培酮组(P<0.01),且从第2周末开始,联用组比两组单用组有显著性差异(P<0.05)。3组各时期TESS评分无显著性差异(P>0.05)。结论利培酮联合氟西汀对无精神病性症状抑郁症的疗效比单用氟西汀或利培酮要好、起效要快,且不显著增加不良反应,但单用利培酮的疗效则不及氟西汀。

关键词: 利培酮, 氟西汀, 无精神病性症状抑郁症

Abstract: Objective To survey the value of risperidone in the treatment of depression without psychotic symptoms. Methods 205 depressive patients were randomly divided into 3 groups: risperidone group, fluoxetine group and combined group (risperidone+fluoxetine). They were assessed with Hamilton Depression Scale (HAMD), Treatment Emergent Symptom Scale (TESS) before treatment and in 2nd week, 4th week, 6th week and 8th week after treatment. Results The reduction rate of HAMD of combined group was the best among three groups(P<0.05), and that of fluoxetine group was better than that of risperidone(P<0.01). The significant difference in reduction rate of HAMD between combined group and other two groups was observed since 2nd week after treatment(P<0.05). No difference in scores of TESS has been observed in any time among three groups. Conclusion Risperidone can improve the efficacy of fluoxetine on depression without psychotic symptoms without increasing side effects, but itself is less effective than fluoxetine.

Key words: risperidone, fluoxetine, depression without psychotic symptoms