《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (06): 508-510.

• 专题　脊柱脊髓损伤康复 • 上一篇    下一篇

脊髓损伤肌萎缩肌球蛋白重链可塑性与训练的影响

范晓华1,2; 纪树荣2,3; 周红俊2,3   

  1. 1.山东省立医院康复医学中心,山东济南市 250021;2.首都医科大学康复医学院,北京市 100068;3.中国康复研究中心北京博爱医院,北京市 100068
  • 收稿日期:2006-11-09 出版日期:2007-06-01 发布日期:2007-06-01

Effect of Spinal Cord Injury and Training on Expression of Myosin Heavy Chain of Skeletal Muscle (review)

FAN Xiao-hua, JI Shu-rong, ZHOU Hong-jun   

  1. The Department of Rehabilitation Medicine, Shandong Provincial Hospital, Jinan 250021, Shandong,China
  • Received:2006-11-09 Published:2007-06-01 Online:2007-06-01

PDF (PC)

被引次数

13

摘要： 骨骼肌的收缩特性部分是由肌球蛋白重链(MHC)亚型决定的。脊髓损伤后损伤水平以下的骨骼肌MHC各亚型mRNA和蛋白水平发生适应性变化,表现为慢MHC-Ⅰ亚型表达下调,快MHC亚型表达上调。MHC-mRNA的适应性变化先于蛋白的变化。不同物种、不同肌肉MHC转化的程度与速度不同。脊髓损伤后短时间训练不能引起MHC亚型发生显著的转化,而长期负重步行训练能够减缓肌纤维MHC亚型表达发生由慢向快的转化。

关键词: 脊髓损伤, 肌萎缩, 肌球蛋白重链, 训练, 综述

Abstract: Skeletal muscle contractile properties are determined by their myosin heavy chain (MHC) expression profiles partly. Spinal cord injury induced the adaptation change in MHC isoform mRNAs and protein expression of skeletal muscle below the injured level, leading to the increased expression of fast and decreased expression of slow MHC isoforms. The adaptations in the MHC-mRNAs preceded the changes in proteins. The degree and velocity of MHC isoform adaptation were dependent on differenrt muscle and animal species. Short-term training could not induce the significant change of the transformation of MHC isoform, whereas long-term stepping training which emphasized load bearing could attenuate the MHC shift from slow toward faster isoforms.

Key words: spinal cord injury, muscle atrophy, myosin heavy chain, training, review