《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (06): 570-571.

• 临床研究 • 上一篇    下一篇

托吡酯治疗糖尿病周围神经病疗效观察

肖天梅1a; 王本国1a; 杨楠1b   

  1. 1.广州中医药大学中山附属医院a.内分泌科;b.神经内科, 广东中山市 528400
  • 收稿日期:2006-10-10 出版日期:2007-06-01 发布日期:2007-06-01

Effect of Topiramate on Diabetic Peripheral Neuropathy

XIAO Tian-mei, WANG Ben-guo, YANG Nan   

  1. The Department of Endocrine, Zhongshan Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Zhongshan 528400, Guangdong, China
  • Received:2006-10-10 Published:2007-06-01 Online:2007-06-01

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摘要： 目的观察托吡酯治疗糖尿病周围神经病的临床疗效。方法83例糖尿病周围神经病患者随机分成对照组40例和治疗组43例,均给予常规降糖及B族维生素支持治疗,治疗组同时给予托吡酯治疗1个月。结果治疗组及对照组的临床总有效率分别为90.7%和67.5%,差异有显著性意义(P<0.05)。治疗后,两组患者的感觉及运动神经传导速度明显提高,但治疗组的传导速度显著高于对照组(P<0.001)。结论在控制血糖基础上,加用托吡酯治疗糖尿病周围神经病临床疗效确切,副作用少。

关键词: 糖尿病周围神经病, 托吡酯, 神经传导速度

Abstract: Objective To investigate the therapeutic effect of topiramate on diabetic peripheral neuropathy.MethodsEighty three patients with diabetic peripheral neuropathy were randomly divided into the control group (n=40) and treatment group (n=43). All patients of two groups were given antidiabetic drugs and vitamine B treatment. While the treatment group was added with topiramate orally for 1 month.ResultsThe total effective rate of the treatment group and control group were 90.7% and 67.5% respectively with a significant difference between two groups ( P<0.05). The velocity of sensory and motor conduction of all patients obviously increased after one month treatment, but the nerve conductive velocity of the patients in the treatment group was significantly higher than that in the control group ( P<0.001).ConclusionOn the basis of lowing blood glucose, using topiramate is more effective on diabetic peripheral neurophy and without obvious side effect.

Key words: diabetic peripheral neuropathy, topiramate, nerve conduction velocity