《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (07): 634-636.

• 综述 • 上一篇    下一篇

褪黑素与神经退行性疾病相关的研究进展

孔祥英1; 左萍萍1; 蔡哲2   

  1. 1.中国医学科学院、中国协和医科大学基础医学研究所,北京市 100005;2.中日友好医院临床医学研究所免疫学研究室,北京市 100029
  • 收稿日期:2006-12-25 出版日期:2007-07-01 发布日期:2007-07-01

Advance in Melatonin Related with Neurodegenerative Disease(review)

KONG Xiang-ying, ZUO Ping-ping, CAI Zhe   

  1. Institute of Basic Medical Science, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China
  • Received:2006-12-25 Published:2007-07-01 Online:2007-07-01

PDF (PC)

被引次数

7

摘要： 氧化应激和线粒体功能失调被认为是神经退行性疾病如阿尔茨海默病和帕金森病共同的病理生理机制。随着年龄的增加,褪黑素水平明显的降低可能是年老人体内氧化应激增加的原因之一,因此褪黑素的神经保护作用日益引起关注。本文就近年褪黑素抗神经退行性疾病的机制,包括自由基清除作用、抑制凋亡、神经保护作用、神经营养作用、抗β-淀粉样蛋白神经毒性、调节炎症反应和调节细胞骨架蛋白等方面作一综述。

关键词: 褪黑素, 神经退行性疾病, 阿尔茨海默病, 帕金森病, 综述

Abstract: Oxidative stress and mitochondria disorder are the common mechanism of neurodegenerative disease, such as Alzheimer disease and Parkinson disease. Melatonin (MT) level decreases with aging may be one of the reasons of the increased oxidative stress in aging people. So the neuroprotective effect of MT becomes more attractive in recent years. This paper summarized recent studies on the mechanism of melatonin on degenerative disease, including free radical scavenge, anti-apoptosis, neuroprotective effect, neurotrophic effect, anti-amyloid neurotoxicity, regulation of inflammatory reaction and cytoskeletal protein etc.

Key words: melatonin, neurodegenerative disease, Alzheimer disease, Parkinson disease, review