《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (07): 645-646.

• 临床研究 • 上一篇    下一篇

阿尔茨海默病患者空腹血糖、真胰岛素、C肽及β淀粉样蛋白的水平

刘卫刚; 田瑞振; 冯亚青; 赵大卫; 郭振华; 王建华; 刘桂芳; 哈志远   

  1. 河北省人民医院老年神经科; 河北省人民医院老年神经科 河北石家庄市; 河北石家庄市
  • 收稿日期:2007-04-17 出版日期:2007-07-01 发布日期:2007-07-01

Level of Fasting Plasma Glucose, True Insulin, C-peptide and Amyloid Beta-protein in Patients with Alzheimer Disease

LIU Wei-gang, TIAN Rui-zhen, FENG Ya-qing, et al   

  1. The People's Hospital of Hebei Province, Shijiazhuang 050051, Hebei, China
  • Received:2007-04-17 Published:2007-07-01 Online:2007-07-01

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摘要： 目的探讨阿尔茨海默病(AD)患者胰岛素及β淀粉样蛋白(Aβ)的异常代谢。方法随机选取70名正常人(对照组)、55例AD患者,检验其空腹血糖、真胰岛素、C肽、Aβ40、Aβ42水平。将AD患者按痴呆轻、中重度分组后与对照组进行比较。结果对照组比较,AD患者各组空腹血糖无显著性差异(P>0.05),中重度组真胰岛素和C肽升高(P<0.05),中重度组Aβ40升高(P<0.05),轻度组Aβ42明显升高(P<0.01)。结论AD患者体内存在胰岛素及β淀粉样蛋白代谢异常,其特征与痴呆的严重程度有关。

关键词: 阿尔茨海默病, 胰岛素, β淀粉样蛋白

Abstract: Objective To investigate the level of insulin and amyloid beta-protein (Aβ) in patients with Alzheimer disease(AD). Methods The levels of fasting plasma glucose, true insulin, C-peptide, Aβ40 and Aβ42 in 70 healthy age-matched adults and 55 patients with AD were measured and analyzed. Results No differences were observed for the levels of fasting plasma glucose between AD groups and normal group (P>0.05). The level of the true insulin and C-peptide of the moderate/severe AD group were significantly higher than that of the normal control group(P<0.05), as well aw that of the Aβ40 (P<0.05). The level of Aβ42 of the mild AD group waw significantly higher than that of the normal control group(P<0.01). Conclusion Plasma insulin and Aβ are abnormal in AD, and they are related to severity of dementia.

Key words: Alzheimer disease, insulin, amyloid beta-protein