《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (08): 718-720.

• 专题　神经损伤康复 • 上一篇    下一篇

小脑顶核刺激脑保护机制研究进展

阿力木江; 张润峰; 胡大一   

  1. 同济大学心肺血管中心,上海市 200092
  • 收稿日期:2006-12-30 出版日期:2007-08-01 发布日期:2007-08-01

Advance in Research on Brain Protection Mechanisms of Fastigial Nucleus Stimulation (review)

AliMuJiang, ZHANG Run-feng,HU Da-yi   

  1. The Center of Heart, Lung and Vascular Diseases, Tongji University, Shanghai 200092, China
  • Received:2006-12-30 Published:2007-08-01 Online:2007-08-01

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被引次数

34

摘要： 有关小脑顶核研究的历史可追寻到19世纪,但对小脑的"邻居"大脑领域的研究进展限制了有关小脑的研究步伐。近30年来,随着小脑顶核刺激脑保护作用的发现,使得该方向的研究得到迅速发展。目前,小脑顶核刺激的脑保护作用已得到公认,具体机制主要集中在改善脑梗死周围的电不稳定性,降低缺血诱发的梗死周围去极化和皮质扩散性抑制;抑制梗死后微血管内的炎症反应;抑制细胞调亡;减少神经元损伤;促进脑缺血后血管新生等方面,笔者对此进行回顾并对进一步的研究方向提出展望。

关键词: 小脑, 顶核, 电刺激, 综述

Abstract: The research on fastigial nucleus could be traced back to 19th century. However the great achievements on cerebrum overshadowed the importance of cerebellum and its nucleus. In recent 30 years, with the finding of brain protection effect of fastigial nucleus stimulation, much attention has been given to this field. Now its widely accepted that electrical stimulation of fastigial nucleus has brain protection effect and concrete mechanisms can be concluded as: improving the electrical instability around the infarct zone, reducing peri-infarction depolarizing wave and cortical spreading depression; suppressing microvessels inflammatory reaction; inhibiting cell apoptosis; reducing the neurons damage and facilitates neovascularization and so on. These new discoveries was reviewed and further expectation on this field was put forward by the authors.

Key words: cerebellum, fastigial nucleus, electrical stimulation, review