《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (09): 876-877.

• 临床研究 • 上一篇    下一篇

通心络对糖尿病患者血管内皮损伤的影响

张爱华; 高昆山; 崔星慧; 王晓玲; 孙金红   

  1. 潍坊医学院附院内分泌科,山东潍坊市 261031
  • 收稿日期:2007-03-12 出版日期:2007-09-01 发布日期:2007-09-01

Effect of Tongxinluo Capsule on Vascular Endothelial Injury in Patients with Diabetes Mellitus

ZHANG Ai-hua, GAO Kun-shan,CUI Xing-hui, et al   

  1. Department of Endocrinology, Affiliated Hospital, Weifang Medical College, Weifang 261031, Shandong, China
  • Received:2007-03-12 Published:2007-09-01 Online:2007-09-01

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被引次数

30

摘要： 目的研究通心络胶囊对糖尿病患者血管内皮细胞功能的影响。方法随机将60例糖尿病(DM)患者分为常规治疗组(30例)和通心络治疗组(30例),后者在糖尿病常规降糖治疗的基础上加用通心络治疗,治疗8周,观察两组用药前后vonWille-brand因子(vWF)、超氧化物歧化酶(SOD)、血糖、血脂等指标的变化。结果治疗后,通心络治疗组vWF明显低于常规治疗组(P<0.01),SOD明显高于常规治疗组(P<0.01),血脂明显低于常规治疗组(P<0.01)。结论通心络能够减轻DM患者的血管内皮细胞的损伤,可以预防和延缓糖尿病并发症的发生和发展。

关键词: 通心络, 糖尿病, 内皮细胞

Abstract: Objective To study the effect of Tongxinluo capsule on vascular endothelial injure in patients with diabetes mellitus.Methods 60 patients with diabetes mellitus were randomly divided into common group and Tongxinluo group.The former was treated with insulin or oral hypoglycemic agents,the latter was added with Tongxinluo capsule oral based on aforesaid therapy.Plasma von Willebrand Factor(vWF)and superoxide dismutase(SOD)were measured before and after treatment.Results After treated with Tongxinluo,The plasma level of vWF was lower than that of common(P<0.01),as well as the level of lipid(P<0.01),while the plasma level of SOD was higher(P<0.01).Conclusion Tongxinluo can protect the of vascular endothelial cells from diabetes mellitus,that may play a role in prevention of the complication.

Key words: Tongxinluo, diabetes mellitus, endothelial cells