《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (12): 1137-1140.

• 综述 • 上一篇    下一篇

神经干细胞与脑梗死康复

杨永轩1a; 郭宗成1a; 贾子善1b   

  1. 1.河北省人民医院a.神经内科;b.康复科,河北石家庄市 050051
  • 收稿日期:2007-05-23 出版日期:2007-12-01 发布日期:2007-12-01

Neural Stem Cells and Ischemic Rehabilitation (review)

YANG Yong-xuan, GUO Zong-cheng, JIA Zi-shan   

  1. The Department of Neurology, Hebei Provincial People's Hospital, Shijiazhuang 050051, Hebei, China
  • Received:2007-05-23 Published:2007-12-01 Online:2007-12-01

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摘要： 近年来的研究证实,成年中枢神经系统内广泛分布着神经干细胞(NSC),海马齿状回颗粒下层和侧脑室下区是成体大脑内源性NSC存在的主要脑区。NSC正常情况下处于静息状态,当大脑受到损伤或出现某些病理性变化时会被激活,分化为成熟的神经细胞,修复受损的神经功能。可以通过某些手段(如康复训练、丰富环境、局部应用外源性神经生长因子)激活自身干细胞或移植干细胞(包括NSC移植和非NSC移植)治疗脑梗死。

关键词: 神经干细胞, 脑梗死, 丰富环境, 移植, 综述

Abstract: Recent studies have indicated that neural stem cells (NSC) distribute in the adult central nervous system generally. Subgranular zone and subventricular zone are the main districts of the endogenous NSC in the adult brain. These cells drowse when they occupy normal condition, and are activated when the brain is injuryed or comes to some pathological change, and then differentiate into mature nerve cell, recovery the damaged nerves function. So the ischemia can be treated by activating endogenous NSC or transplanting exogenous stem cells. The activating means include rehabilitation training, enriched environment and utilizing exogenous nerve growth factors. Stem cells transplantation include NSC transplantation and non-NSC transplantation.

Key words: neural stem cell (NSC), ischemia, enriched environment, transplantation, review