《中国康复理论与实践》

《中国康复理论与实践》 ›› 2007, Vol. 13 ›› Issue (12): 1171-1173.

• 临床研究 • 上一篇    下一篇

甲基强的松龙冲击治疗颅内幕上肿瘤脑水肿疗效观察

张伟1; 王宇2; 齐巍1; 张懋植1   

  1. 1.首都医科大学附属北京天坛医院神经外科,北京市 100050;2.中国康复研究中心北京博爱医院神经外科,北京市 100068
  • 收稿日期:2007-09-10 出版日期:2007-12-01 发布日期:2007-12-01

Effect of High-dose Methylprenisolone Pulse Treatment on Peritumor Edema Induced by Supratentorial Brain Tumors

ZHANG Wei,WANG Yu, QI Wei, et al   

  1. The Department of Neurosurgery, BeijingTiantan Hospital Affiliated to Capital Medical Universi- ty, Beijing 100050, China
  • Received:2007-09-10 Published:2007-12-01 Online:2007-12-01

PDF (PC)

被引次数

24

摘要： 目的观察大剂量甲基强的松龙冲击治疗对幕上脑肿瘤瘤周水肿的临床疗效和不良反应。方法选择35例幕上脑肿瘤伴瘤周水肿患者术前应用甲基强的松龙冲击治疗,采用MRI测算每个患者冲击治疗前后的水肿指数。结果甲基强的松龙冲击治疗后,轻度、中度、重度瘤周水肿患者的平均水肿指数分别减少1.79%、8.81%和12.02%,中度和重度患者的水肿指数明显低于治疗前(P<0.01),轻度患者的水肿指数与治疗前的差异无显著性意义(P>0.05)。结论大剂量甲基强的松龙冲击治疗对中度及重度幕上脑肿瘤瘤周水肿有明显的治疗作用,无严重不良反应。

关键词: 甲基强的松龙, 冲击治疗, 瘤周水肿, 水肿指数

Abstract: Objective To observe the clinical efficacy and adverse reactions of high-dose methylprednisolone pulse treatment on peritumoral edema induced by supratentorial brain tumors.Methods Thirty-five patients with supratentorial brain tumors and peritumoral edema were treated with methylprednisolone pulse therapy before surgery and the edema index of every patient was calculated by MRI examinations before and after methylprednisolone treatment.Results After methylprednisolone pulse therapy, the edema indexes of the light, medium and severe edema patients reduced by 1.79%, 8.81% and 12.02% respectively. The edema indexes of the medium and serious patients were significantly lower than that before treatment ( P<0.01). But the edema index of the light edema patients was not significantly different with that before treatment ( P>0.05).Conclusion High-dose methylprednisolone pulse therapy has an obvious effect on medium and serious peritumoral edema induced by supratentorial brain tumors and has no serious adverse reactions.

Key words: methylprednisolone, pulse treatment, peritumoral brain edema, edema index