《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (01): 38-40.

• 综述 • 上一篇    下一篇

多发性硬化的蛋白质组学研究进展

郑能 综述; 吴卫平 审校   

  1. 中国人民解放军总医院神经内科,北京市 100853
  • 收稿日期:2007-07-21 出版日期:2008-01-01 发布日期:2008-01-01

Advance in Proteomics Analysis of Multiple Sclerosis (review)

ZHENG Neng-tao, WU Wei-ping   

  1. Department of Neurology, the General Hospital of PLA, Beijing 100853, China
  • Received:2007-07-21 Published:2008-01-01 Online:2008-01-01

摘要: 对多发性硬化患者蛋白质组学分析有助于对进一步认识多发性硬化的分子病理特征,选择适宜的样本制备与蛋白质分离、鉴定方法,有望发现与多发性硬化相关的特异性蛋白质,为多发性硬化的诊断、治疗、预防提供新的线索,提高疑似病例的确诊率;针对特异性蛋白质进行干预有可能减轻症状、预防复发;探索药物或基因治疗方法。

关键词: 多发性硬化, 蛋白质组学, 综述

Abstract: Proteomics analysis of multiple sclerosis will provide more molecular pathology information about it.With appropriated methods of sample preparation,protein separation and identification,some proteins related to multiple sclerosis could be found and helpful for diagnosis,treatment and prophylaxis.This will improve the final diagnosis ratio of suspected cases and offer clue of drug and gene therapy exploration.Intervention of the related protein ameliorate symptom and release relapse.

Key words: multiple sclerosis, proteomics, review