《中国康复理论与实践》

《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (01): 62-64.

• 临床研究 • 上一篇    下一篇

促红细胞生成素与炎性细胞因子在脑瘫发病中的作用

陶维元1a; 文芳1b; 姚汉云1a; 孙杨1a   

  1. 1.武汉大学人民医院,a.神经内科;b.神经精神病研究所,湖北武汉市 430060
  • 收稿日期:2007-09-12 出版日期:2008-01-01 发布日期:2008-01-01

Influence of Erythropoietin and Inflammatory Cytokines on Pathogenesis of Cerebral Palsy

TAO Wei-yuan, WEN Fang, YAO Han-yun, et al   

  1. Department of Neurology, People's Hospital, Wuhan University, Wuhan 430060, Hubei, China
  • Received:2007-09-12 Published:2008-01-01 Online:2008-01-01

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被引次数

11

摘要： 目的探讨脑保护因子促红细胞生成素(EPO)与免疫炎性细胞因子在脑瘫发病中的作用。方法检测31例脑瘫患儿(脑瘫组)和20名健康儿童(脑瘫对照组)及37例脑瘫高危因素新生儿(新生儿病例组)和20名正常新生儿(新生儿对照组)的血清EPO、肿瘤坏死因子(TNF)-α和白细胞介素(IL)-6水平。结果新生儿病例组血清EPO水平明显高于新生儿对照组和脑瘫组(P<0.01),脑瘫组血清EPO水平与脑瘫对照组比较无显著性差异(P>0.05);新生儿病例组血清TNF-α和IL-6水平明显高于新生儿对照组(P<0.01);脑瘫组血清TNF-α和IL-6水平明显高于脑瘫对照组(P<0.01),脑瘫组血清TNF-α水平高于新生儿病例组(P<0.05),但两者间IL-6水平无显著性差异(P>0.05)。结论炎性细胞因子介导的脑破坏作用在与EPO的神经保护作用的抗衡中占据优势,促进或导致脑瘫的发生。

关键词: 脑性瘫痪, 促红细胞生成素, 炎性细胞因子, 肿瘤坏死因子(TNF), 白细胞介素(IL), 免疫-神经-内分泌网络

Abstract: Objective To investigate the effect of erythropoietin(EPO)as a brain-protective factor and inflammatory cytokines in the pathogenesis of cerebral palsy(CP).Methods Serum samples from 31 CP patients,37 neonates with CP risk factors such as hypoxic-ischemic injury and/or perinatal infection,and 20 controls of neonates or children were obtained respectively.EPO,tumor necrosis factor(TNF)-α and interleukin(IL)-6 levels were measured with the enzyme-linked immunosorbent assay double sandwich method(ABC-ELISA).Results The serum EPO level of neonatal patients was higher than that of controls or CP group(P<0.01),but there was no significant difference between CP group and controls.The serum TNF-α and IL-6 levels of CP and neonatal patients were higher than that in controls(P<0.01).The serum TNF-α level of CP group was higher than that of neonatal patients(P<0.05).There was no significant difference between CP group and neonatal patients in serum IL-6 level.Conclusion The inflammatory responses mediated by proinflammatory cytokines may play a role in the pathogenesis of cerebral palsy.

Key words: cerebral palsy, erythropoietin(EPO), inflammatory cytokine, tumor necrosis factor(TNF), interleukin(IL), neuro-immune-endocrine network