《中国康复理论与实践》

《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (02): 138-140.

• 基础研究 • 上一篇    下一篇

视频密度阶差评价心肌微灌注的实验研究

杨霞; 刘宏斌; 盖鲁粤; 杜洛山; 王立军   

  1. 解放军总医院心内科,北京市 100853
  • 收稿日期:2007-08-03 出版日期:2008-02-01 发布日期:2008-02-01

Experimental Study of Videodensitometric Scale to Assess Myocardial Microperfusion

YANG Xia, LIU Hong-bin, GAI Lu-yue, et al.   

  1. The Department of Cardiology, the General Hospital of PLA, Beijing 100853, China
  • Received:2007-08-03 Published:2008-02-01 Online:2008-02-01

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摘要： 目的探讨视频密度阶差(VDS)评价心肌微灌注的可行性及应用价值。方法11只犬应用聚苯乙烯微泡(直径100μm)栓塞冠状动脉,6只栓塞前降支(LAD),5只栓塞回旋支(LCX)。栓塞前后分别行冠状动脉造影;栓塞后12h行心肌声学造影超声心动图(MCE)检查;分析冠状动脉造影前后的VDS及MCE积分(MCES)。结果11只犬栓塞前的VDS为(24.4±4.9),栓塞后的VDS为(15.2±3.8),栓塞后的VDS低于栓塞前(P<0.05)。LAD及LCX之间同期VDS的差异无统计学意义;栓塞后的MCES为(7.6±2.4),与VDS呈负相关(γ=-0.78,P<0.05)。结论VDS作为一个新的定量指标,与MCES存在较好的相关性,可作为临床上评价心肌微灌注的定量指标。

关键词: 视频密度阶差, 心肌声学造影超声心动图, 心肌微灌注

Abstract: Objective To evaluate the feasibility and the value of videodensitometric scale(VDS)assessing myocardial microperfusion.Methods The small coronary arteries of 11 dogs were embolized by ejecting polystyrene microbubble(dm= 100 μm),six embolized at left anterior descending branch(LAD)and five embolized at left circumflex branch(LCX).Coronary angiography was performed before and after the embolization.The myocardial contrast echocardiography(MCE)was performed in 12th hour after embolization.VDS was calculated according to coronary angiography.MCE scales were calculated.Results Among the eleven experimental dogs,VDS before embolization was 24.4±4.9 and that after embolization was 15.2±3.8.VDS after embolization was obviously lower than before embolization(P<0.05).VDS between LAD and LCX at the same stage was no difference;MCE scores after embolization were 7.6±2.4.VDS was negatively dependent with MCES after embolization(γ=-0.78,P<0.05).Conclusion As a newly quantitative index and keeping a closely correction with MCE,VDS can be used as a quantitative index to assess myocardial microperfusion in clinic.

Key words: videodensitometric scale, myocardial contrast echocardiography(MCE), myocardial microperfusion