《中国康复理论与实践》

《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (03): 255-256.

• 临床研究 • 上一篇    下一篇

高压氧治疗对脑外伤患者外周血CD34+细胞的影响

于强; 袁志诚; 陆培松   

  1. 江苏大学附属人民医院神经外科,江苏镇江市 212002
  • 收稿日期:2007-08-31 出版日期:2008-03-01 发布日期:2008-03-01

Expression of Peripheral Blood CD34++ Cells before and after Hyperbaric Oxygen Treatment in Patients with Brain Traumatic Injury

YU Qiang, YUAN Zhi-cheng, LU Pei-song   

  1. People's Hospital Affiliated to Jiangsu University, Zhenjiang 212002,Jiangsu, China
  • Received:2007-08-31 Published:2008-03-01 Online:2008-03-01

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摘要： 目的观察高压氧治疗期间脑外伤康复期患者外周血CD34+细胞和白细胞的变化。方法接受高压氧治疗的脑外伤康复期患者11例,在高压氧治疗前、治疗期第1、2、3、4、5周,分别计数外周血CD34+细胞、白细胞,正常人11名作为对照。结果与对照组比较,脑外伤康复期患者外周血CD34+细胞在高压氧治疗第1、3周无明显变化,第2、5周上升(P<0.05);治疗组内比较,治疗第1、3周与第5周有显著性差异(P<0.05)。治疗期间白细胞计数处正常范围,与对照组无显著性差异。患者临床症状有改善。结论高压氧治疗对以CD34+标识的骨髓源干细胞有动员作用,可能通过动员CD34+细胞,参与脑外伤康复期的神经功能修复。

关键词: 高压氧, 脑外伤, CD34+细胞

Abstract: Objective To investigate the change of peripheral blood CD34+ cells and white blood cells(WBC)count in the patients with brain traumatic injury in convalescence stage during hyperbaric oxygen(HBO)treatment.Methods The peripheral blood CD34+ cells and WBC count were measured in 11 patients with brain traumatic injury in convalescence stage who accepted HBO treatment before and 1,2,3,4,and 5 weeks during the treatment.Other 11 persons were measured once as controls.Results Compared with the controls,the number of CD34+ cells showed normal in the 1st and the 3rd week,but increased in the 2nd and the 5th week in the HBO group(P<0.05).It was increased in the 5th week compared with that in the 1st and the 3rd week(P<0.05)in the treatment group.The number of WBC showed no significance and the patients' symptoms improved during the HBO treatment.Conclusion HBO can mobilize bone marrow derived stem cells marked by CD34,which may participate in the restoration of brain traumatic injury in convalescence stage.

Key words: hyperbaric oxygen, brain traumatic injury, CD34+ cells