《中国康复理论与实践》

《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (03): 281-282.

• 临床观察 • 上一篇    下一篇

托吡酯联合丙戊酸钠、氯硝西泮治疗难治性癫痫临床观察

胡萌; 刘欣友; 李臻; 张中银   

  1. 中山大学附属东华医院,广东东莞市 523110
  • 收稿日期:2008-01-04 出版日期:2008-03-01 发布日期:2008-03-01

Combination of Topiramate,Sodium Valproate and Clonazepam for Intractable Epilepsy:157 Cases 2-year Follow-up

HU Meng, LIU Xin-you, LI Zhen, et al   

  1. Donghua Hospital, Zhongshan University, Dongguan523110, Guangdong, China
  • Received:2008-01-04 Published:2008-03-01 Online:2008-03-01

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摘要： 目的探讨托吡酯联合丙戊酸钠、氯硝西泮治疗难治性癫痫的疗效。方法对符合标准的157例难治性癫痫患者给予氯硝西泮、丙戊酸钠、托吡酯。观察治疗3个月、6个月、1年、2年后的疗效和不良反应。结果治疗6个月后总有效率为75.16%,随着时间的延长疗效进入平稳期;对各种发作类型都有很好的控制作用,不良反应轻微。结论托吡酯联合丙戊酸钠、氯硝西泮治疗难治性癫痫疗效确切,安全性高。

关键词: 托吡酯, 丙戊酸钠, 氯硝西泮, 难治性癫痫

Abstract: Objective To investigate the effect of combination of topiramate,sodium valproate and clonazepam on intractable epilepsy.Methods 157 Patients with intractable epilepsy were treated with clonazepam,sodium valproate and topiramate.They were followed up for 2 years.Results The total efficiency is 75.16% 6 months after treatment,which was steady in the latter time and reliable for various types of attack,with few side-effects.Conclusion Combination of topiramate,sodium valproate and clonazepam is effective and safe on intractable epilepsy.

Key words: topiramate, sodium valproate, clonazepam, intractable epilepsy