《中国康复理论与实践》

《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (04): 319-320.

• 专题 • 上一篇    下一篇

益气活血化痰方干预稳定性冠心病患者炎症反应的临床研究

薛金贵1; 王肖龙1; 陈铁军1; 李芹2   

  1. 1.上海中医药大学附属曙光医院心内科,上海市 201203 2.济南机车医院内科,山东济南市 250022
  • 收稿日期:2007-12-18 出版日期:2008-04-01 发布日期:2008-04-01

Clinical Study of Yiqi-huoxue and Huatan Formula on Inflammation Reactivation in Patients with Stable Coronary Heart Disease

XUE Jin-gui, WANG Xiao-long, CHEN Tie-jun, et al   

  1. The Department of Cardiology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • Received:2007-12-18 Published:2008-04-01 Online:2008-04-01

PDF (PC)

被引次数

15

摘要： 目的观察益气活血化痰方对稳定性冠心病患者炎症反应的抑制作用。方法60例气虚血瘀痰阻的稳定性冠心病患者随机分为对照组30例(西药常规治疗)和治疗组30例(在西药常规治疗基础上加用益气活血化痰方),疗程1个月。结果对照组和治疗组治疗前后的CD40配体(CD40L)浓度无显著性改变(P>0.05),基质金属蛋白酶9(MMP-9)差异有显著性意义(P<0.05);与对照组比较,治疗组治疗后CD40L和MMP-9均有显著性改变(P<0.05)。结论益气活血化痰方可通过降低血清CD40L、MMP-9浓度,抑制炎症反应的起始和发展,稳定动脉粥样斑块,减少冠脉事件的发生。

关键词: 益气活血化痰方, 稳定性冠心病, 炎症

Abstract: Objective To observe the effect of Yiqi-huoxue and Huatan formula on inflammation reactivation in stable coronary heart disease(CHD).Methods 60 cases with stable CHD were randomly divided into the control group(30 cases,treated with routine therapy)and study group(30 cases,treated with routine therapy plus Yiqi-huoxue and Huatan formula).Duration was one month.Results There was no significant difference of concentration of CD40L before and after treatment in the control and study groups(P>0.05).There was a significant difference in concentration of matrix metalloproteinase-9(MMP-9)before and after treatment in the control and study groups(P<0.05).There were significant changes of CD40L and MMP-9 in the study group than in the control group(P<0.05).Conclusion Yiqi-huoxue and Huatan formula can decrease serum concentration of CD40L and MMP-9,and inhibit initiation and development of inflammation reactivation,furthermore stable atherosclerotic plaque and reduce coronary events.

Key words: Yiqi-huoxue and Huatan formula, stable coronary heart disease, inflammation