《中国康复理论与实践》

《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (04): 345-346.

• 基础研究 • 上一篇    下一篇

电针对实验性膝骨关节炎大鼠软骨转化生长因子β1表达的影响

包飞1a; 王道海1a; 王凤琴1a; 孙华1a; 李兵1b; 张云祥1a; 吴志宏1b   

  1. 1.中国医学科学院北京协和医学院北京协和医院a.中医科;b.骨科,北京市 100730
  • 收稿日期:2007-08-23 出版日期:2008-04-01 发布日期:2008-04-01

Effect of Electro-acupuncture on Expression of Transforming Growth Factor-β1 in the Cartilage of Experimental Rats with Knee Osteoarthritis

BAO Fei, WANG Dao-hai, WANG Feng-qin, et al.   

  1. The Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijng 100730, China
  • Received:2007-08-23 Published:2008-04-01 Online:2008-04-01

PDF (PC)

被引次数

50

摘要： 目的探讨电针对膝骨关节炎(OA)软骨修复的影响。方法40只SD雌性大鼠随机分为正常组、模型组、治疗组、对照组各10只。造模手术4周后分别对治疗组左膝和对照组右膝采用电针治疗2周。实验第7周收集每只动物左侧膝关节股骨端软骨,进行组织病理切片和HE染色及免疫组化染色,观察转化生长因子β1(TGF-β1)在软骨组织表达的特点。结果治疗组软骨TGF-β1的表达明显增强,与其他各组的差异有非常显著性意义(P<0.01)。结论电针治疗可明显上调实验性OA大鼠膝关节软骨TGF-β1的表达,促进软骨修复。

关键词: 电针, 骨关节炎, 转化生长因子β1

Abstract: Objective To investigate the effect of electro-acupuncture on cartilage renovation of knee osteoarthritis.Methods 40 female SD rats were randomly divided into the normal group,model group,electro-acupuncture treatment group and control group.The left knees of the treatment group and right ones of the control group were treated by electro-acupuncture for two weeks from the fifth week since operation.Collected left knees' cartilage of all rats at the seventh week since the beginning of experiment.HE and immunohistochemical staining were used to observe the expression characteristic of transforming growth factor-β1(TGF-β1)in cartilage.Results The expression of TGF-β1 in the treatment group was very significantly stronger than all other groups(P<0.01).Conclusion Electro-acupuncture can obviously up-regulate the level of TGF-β1 in cartilage of experimental rats with knee osteoarthritis,and promote the repair of cartilage.

Key words: electro-acupuncture, osteoarthritis, transforming growth factor-β1(TGF-β1)