《中国康复理论与实践》

《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (04): 366-367.

• 临床研究 • 上一篇    下一篇

脑卒中患者强制性使用运动治疗的fMRI研究

温博1a; 马林1a; 瓮长水1b; 郑志新1c; 孙彤1c   

  1. 1.解放军总医院a.放射诊断科;b.南楼康复医学科;c.康复医学科;北京市 100853
  • 收稿日期:2008-02-28 出版日期:2008-04-01 发布日期:2008-04-01

A fMRI Study of Cortical Reorganization in Chronic Stroke Hemiplegia Treated with Constraint-induced Movement Therapy

WEN Bo,MA Lin, WENG Chang-shui, et al.   

  1. The Department of Radiology, the General Hospital of PLA, Beijing 100853, China
  • Received:2008-02-28 Published:2008-04-01 Online:2008-04-01

PDF (PC)

被引次数

52

摘要： 目的研究脑卒中偏瘫患者进行强制性使用运动疗法(CIMT)治疗前后fMRI的脑功能区激活变化。方法对5例后遗症期脑卒中患者进行上肢动作研究量表评价;fMRI试验采用组块设计,使用3.0T磁共振仪进行fMRI数据采集,在CIMT治疗前后对患者进行fMRI扫描。结果CIMT治疗后,患者患侧上肢运动功能显著改善(P<0.001),fMRI检查显示患侧运动区手部支配区域激活范围明显局限化,激活强度增加,临近激活区域明显减少,对侧代偿激活区域范围缩小。结论CIMT可以有效改善脑卒中患者上肢运动功能,诱发大脑皮质功能重塑是其机制的重要组成部分。

关键词: 脑卒中, 强制性使用运动疗法, 功能重组

Abstract: Objective To investigate the evidence of cortical reorganization in stroke hemiplegia treated with constraint-induced movement therapy(CIMT)by fMRI.Methods Five patients with chronic stroke were evaluated with the Action Research Arm Test(ARAT).The functional MRI(fMRI)was performed on a 3.0-T MRI with echo-planar imaging.The subjects were required to finish the finger-tapping task and undergo fMRI before and after CIMT.A block design was used for the inspection.Results After CIMT,the function of upper limb(sick side)of patients improved significantly assessed by ARAT(P<0.001),and cortical reorganization was found on fMRI.Conclusion CIMT can improve motor function of upper limb of chronic stroke patients with hemiplegia and induce cortical reorganization as measured by fMRI.

Key words: stroke, constraint-induced movement therapy, functional reorganization