《中国康复理论与实践》

《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (05): 424-426.

• 基础研究 • 上一篇    下一篇

老年人代谢综合征对淋巴细胞亚群的影响

吴晓琰; 陆怡; 施小梅   

  1. 复旦大学附属华山医院老年科,上海市 200040
  • 收稿日期:2008-02-27 出版日期:2008-05-01 发布日期:2008-05-01

Changes of T-lymphocyte Subsets Associated with Metabolic Syndrome in the Aged

WU Xiao-yan, LU Yi, SHI Xiao-mei   

  1. Department of Geriatrics, Huashan Hospital, Fudan University, Shanghai 200040, China
  • Received:2008-02-27 Published:2008-05-01 Online:2008-05-01

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摘要： 目的了解老年人代谢综合征对患者淋巴细胞亚群的影响。方法将入选的1105名老年人分为代谢综合征组和非代谢综合征组,以流式细胞术测定患者CD3+、CD4+、CD8+、CD19+、自然杀伤(NK)细胞。结果CD3+、CD19+、NK细胞在两组间没有显著性差异,而CD4+/CD8+在代谢综合征组下降(P<0.05),并随代谢综合征合并症的增加而下降(P<0.001)。多因素回归分析显示代谢综合征有致CD4+/CD8+降低的效应。结论老年人代谢综合征同时伴随着细胞免疫调节功能的紊乱。

关键词: 代谢综合征, 免疫, 淋巴细胞

Abstract: Objective To investigate the correlation of subtypes of the lymphocytes with metabolic syndrome in the aged.Methods 955 aged male and 150 aged female were recruited to a cross-sectional case-control study.CD3+,CD4,CD8+,CD19+,NK cell was measured with flow cytometry.ResultsCD3+,CD19+,NK cells showed no difference in cases and in controls.CD4+/CD8+ ratio declined in subjects with metabolic syndrome,and the ratio declined further with the more criteria.The analysis of multiple analysis regression showed that metabolic syndrome depressed CD4+/CD8+ ratio in the aged.Conclusion Metabolic syndrome was correlated with the disorder of immunity.

Key words: metabolic syndrome, immunity, lymphocyte