《中国康复理论与实践》

《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (06): 501-503.

• 专题 •    下一篇

神经胶质-免疫机制在疼痛中的作用

程涓1; 张策2   

  1. 1.北京中医药大学附属北京东直门医院病理科,北京市 100700;2.山西医科大学生理学教研室,山西太原市 030001
  • 收稿日期:2008-05-18 出版日期:2008-06-01 发布日期:2008-06-01

Glia-immunity Interactions Underlying Mechanisms of Pain (review)

CHENG Juan, ZHANG Ce   

  1. The Department of Pathology,Beijing Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
  • Received:2008-05-18 Published:2008-06-01 Online:2008-06-01

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摘要： 疼痛产生和维持的机制研究一直局限于神经元及由此形成的网络,对组成神经系统的另一类细胞——神经胶质细胞关注甚少。神经胶质细胞在疼痛机制中的作用,是今后疼痛研究的新方向。作者通过探讨神经胶质-免疫机制在神经病理痛发生和维持中的作用,希望为今后镇痛药物研究提供新的靶点。

关键词: 疼痛, 神经胶质细胞, 免疫

Abstract: Pain is classically viewed as being mediated solely by neurons. This view is dramatically changing by new research that spinal cord glial cells amplify pain. Recognition that glial activation is a powerful driving force for exaggerated pain opens up new ways to approach effective clinical pain control. The authors reviewed spinal cord glial cells and cytokines as key players in the creation and maintenance of neuropathic pain.

Key words: pain, glial cell, immunity