《中国康复理论与实践》

《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (06): 528-530.

• 基础研究 • 上一篇    下一篇

斜床站立和生脉饮对兔脊髓损伤后α1肾上腺素受体的影响

潘钰1; 张庆民2; 关骅3   

  1. 1.首都医科大学宣武医院康复医学科,北京市 100053;2.北京市康复中心骨科,北京市 100041;3.中国康复研究中心北京博爱医院脊柱脊髓外科,北京市 100068
  • 收稿日期:2008-02-22 出版日期:2008-06-01 发布日期:2008-06-01

Effect of Tilting Table Exercise and Shengmaiyin on Alpha 1 Adrenogenic Receptor after Spinal Cord Injury in Rabbits

PAN Yu,ZHANG Qing-min, GUAN Hua   

  1. Capital Medical University Xuanwu Hospital, Beijing 100053, China
  • Received:2008-02-22 Published:2008-06-01 Online:2008-06-01

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摘要： 目的观察斜床站立训练和生脉饮治疗对脊髓损伤(SCI)后兔肠系膜上动脉α1肾上腺素受体(α1AR)的影响。方法46只日本大耳白兔分为假手术组(n=6)、SCI组(n=10,简称损伤组)、SCI+生脉饮组(n=10,简称生脉饮组)、SCI+训练组(n=10,简称训练组)和SCI+生脉饮+斜床站立训练组(n=10,简称联合治疗组)。建立T5脊髓横断动物模型,术后第4天开始斜床站立训练和/或服用生脉饮,共治疗28d。用RT-PCR方法检测术后31d各组动物肠系膜上动脉α1a、α1b、α1dAR mRNA表达变化。结果生脉饮组、训练组、联合治疗组α1aAR、α1bAR、α1dAR mRNA表达与损伤组比较有不同程度的增强。结论生脉饮和斜床站立训练改善SCI后直立性低血压可能与上调肠系膜上动脉α1aAR、α1bAR、α1dAR mRNA表达有关。

关键词: 斜床站立训练, 生脉饮, 脊髓损伤, 直立性低血压, α1肾上腺素受体

Abstract: Objective To observe the effect of tilting table exercise and shengmaiyin on alpha 1 adrenogenic receptor (α1AR) in the superior mesenteric artery after spinal cord injury (SCI) in rabbits.Methods 46 rabbits were randomly divided into the sham group (n=6), SCI group (n=10), shenmaiyin group (n=10), exercise group (n=10) and combined treatment (shenmaiyin plus exercise) group (n=10). The rabbit model of SCI was established by complete transection of spinal cord at the T5 spinal segment. Tilting table exercise and shengmaiyin were applied to different groups for 28 days from 4 days after operation. The expression of α1aAR,α1bAR,α1dAR mRNA in the superior mesenteric artery was detected by RT-PCR at 31d after SCI.Results The mRNA expressions of α1aAR, α1bAR, α1dAR subtypes increased to different extent in rabbits of the shengmaiyin group, exercise group and combined treatment group compared with those of SCI group.Conclusion The role of tilting table exercise and shengmaiyin improving orthostatic hypotension after SCI in rabbits may be related to up-regulation of α1aAR, α1bAR, α1dAR mRNA in the superior mesenteric artery.

Key words: tilting table exercise, shengmaiyin, spinal cord injury, orthostatic hypotension, alpha 1 adrenogenic receptor