《中国康复理论与实践》

《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (06): 557-559.

• 临床研究 • 上一篇    下一篇

肿瘤坏死因子α与慢性阻塞性肺疾病相关性研究

龚燕1; 金美玲2a; 任涛3; 白冲4; 蔡映云2b   

  1. 1.复旦大学附属华山医院老年科,上海市 200040;2.复旦大学附属中山医院a.呼吸科;b.老年科;上海市 200032,3.同济大学附属东方医院呼吸科;上海市 200012,4.第二军医大学附属长海医院呼吸科,上海市 200433
  • 收稿日期:2008-02-27 出版日期:2008-06-01 发布日期:2008-06-01

Relationship between Tumor Necrosis Factor-alpha and Smoking-related Chronic Obstructive Pulmonary Disease

GONG Yan, JIN Mei-ling, REN Tao, et al   

  1. The Department of Gerontology, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China
  • Received:2008-02-27 Published:2008-06-01 Online:2008-06-01

PDF (PC)

摘要： 目的探讨肿瘤坏死因子α(TNF-α)与慢性阻塞性肺疾病(COPD)发生和发展的关系。方法用Th1/Th2细胞因子分析试剂盒测定吸烟COPD组(n=66)、吸烟非COPD组(n=42)和不吸烟非COPD组(n=43)血清TNF-α的浓度,比较重度COPD组(n=23)和轻中度COPD组(n=43)的血清TNF-α浓度。结果吸烟COPD组血中TNF-α的浓度为(0.72±1.19)pg/ml,明显高于吸烟非COPD组的(0.05±0.29)pg/ml及不吸烟非COPD组的(0.11±0.11)pg/ml(均P<0.01),重度COPD组的TNF-α浓度为(1.25±1.01)pg/ml,高于轻中度COPD组的(0.48±0.71)pg/ml(P<0.05)。结论血清TNF-α浓度与COPD的发生及其严重程度有关。

关键词: 慢性阻塞性肺疾病, 肿瘤坏死因子α, 吸烟

Abstract: Objective To investigate the relationship between tumor necrosis factor-alpha (TNF-α) and development of chronic obstructive pulmonary disease (COPD).Methods COPD patients and controls were divided into three groups: COPD group (n=66), smoker control group (n=42) and health control group (n=23). COPD group was further divided into the serious group (n=23) and non-serious group (n=43). The concentration of TNF-α of all cases was detected by human Th1/Th2 cytokine kit.Results The concentration of TNF-α in the COPD group was significantly higher than that of the smoker and healthy groups ( P<0.01). Furthermore, compared to non-serious COPD group, the concentration of TNF-α was higher in the serious COPD group ( P<0.05).Conclusion The concentration of TNF-α might be related with the pathogenesis and development of COPD.

Key words: chronic obstructive pulmonary disease (COPD), tumor necrosis factor-alpha (TNF-α), smoking