《中国康复理论与实践》

《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (08): 710-712.

• 专题 • 上一篇    下一篇

Nogo的作用机制和受体干预

卢占斌; 孙来卿; 陈先; 刘兰泽; 王立功   

  1. 唐山市第二医院脊髓损伤科,河北唐山市 063000
  • 收稿日期:2008-03-10 出版日期:2008-08-01 发布日期:2008-08-01

Active Mechanism of Nogo and Intervention to Nogo Receptor (review)

LU Zhan-bin, SUN Lai-qing, CHEN Xian, et al   

  1. The Department of Spinal Cord Injury, the Second Hospial of Tangshan, Tangshan 063000, Hebei, China
  • Received:2008-03-10 Published:2008-08-01 Online:2008-08-01

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摘要： Nogo是一个与中枢髓磷脂结合的特异性的抑制因子。脊髓损伤后,少突胶质细胞和髓磷脂释放出Nogo-A到细胞外基质,抑制轴突再生。通过分析Nogo受体的细胞外分子干预、细胞内信息干预和基因干预,了解对Nogo受体介导的髓磷脂相关抑制因子的抑制,为脊髓损伤后轴突的再生提供了新的思路和方法。

关键词: Nogo受体, 脊髓损伤, 轴突, 再生, 综述

Abstract: Nogo receptor is specific inhibiting factor conjuncted with myelin of central nervous system(CNS).After spinal cord injury,oligodendroglial cell and Nogo-A released from myelin inside cells inhibited the axonal regeneration.To analyze the intervention for Nogo receptor through molecule outside cell,information inside cell and gene,make clearing the inhibiting action of myelin-associated inhibiting factor-1,provide new thoughts and methods about axonal regeneration after spinal cord injury.

Key words: Nogo receptor, spinal cord injury, axonal, regeneration, review