《中国康复理论与实践》

《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (10): 909-911.

• 专题 • 上一篇    下一篇

胰岛素抵抗与青年脑卒中

冯艳蓉1a; 吴亚平1b; 郝姜蕾1a   

  1. 1.南京同仁医院a.神经内科;b.内分泌科,江苏南京市 211100
  • 收稿日期:2008-05-19 出版日期:2008-10-01 发布日期:2008-10-01

Relationship between Insulin Resistance and Young Adult Stroke(review)

FENG Yan-rong, WU Ya-ping, HAO Jiang-lei   

  1. Nanjing Tongren Hospital, Nanjing 211100, Jiangsu, China
  • Received:2008-05-19 Published:2008-10-01 Online:2008-10-01

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摘要： 脑卒中是多种危险因素所致的疾病,胰岛素抵抗(IR)与脑卒中的关系是目前研究的热点之一。IR是指机体靶组织器官对胰岛素反应性降低或丧失而产生的一系列病理生理变化,其检测方法有多种,其中胰岛素敏感指数(ISI)能较好地反映胰岛素的敏感性。IR可引起包括高胰岛素血症、高血糖、高血压、血脂紊乱、纤维蛋白溶解系统异常、血管内皮功能改变、动脉粥样硬化等在内的一系列病理生理变化,可能是通过多种代谢性危险因素而致病。而早发性动脉粥样硬化是青年脑卒中的主要病因。由此推断,青年脑卒中也存在IR。但是不同类型的青年脑卒中是否均存在IR?机制如何?IR的程度与青年脑卒中的病情及预后是否相关?这些问题目前尚不清楚,两者关系的研究对于青年脑卒中的防治具有重要意义。

关键词: 胰岛素抵抗, 青年脑卒中, 综述

Abstract: Stroke is the disease which caused by many risk factors.The relationship between insulin resistance(IR) and young adult stroke is one of the focuses now in the neurological field.IR refered to the series of pathological and physiological changes,it happens when the response of the target tissue organ to insulin is depressing or losing.There are many ways of detection of IR,the insulin sensitivity index(ISI) is one of the most satisfied indexes to reflect the sensitivity to insulin.IR could cause a series of pathological and physiological changes,which caused hyperinsulinemia,hyperglycemia,hyperpiesia,blood-fat derangement,fibrinolytic system anomaly,blood vessel endothelium change,artherosclerosis,et al,maybe in ways of many metabolic risk factors.Atherosclerosis is the main etiopathogenisis factor in young adult stroke,as a conclusion,IR is also existed in young adult stroke.But,does IR exist in all types of young adult stroke? What is the mechanism? Is the level of IR related with the pathogenetic condition and prognosis? These questions are still not clear at present,and the study on the relationship between IR and young adult stroke is important to prevent young adult stroke.

Key words: insulin resistance, young adult stroke, review