《中国康复理论与实践》

《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (10): 927-929.

• 专题 • 上一篇    下一篇

单周期低频重复经颅磁刺激对帕金森病的短时程疗效

冯涛; 王拥军; 李伟   

  1. 首都医科大学附属北京天坛医院神经内科,北京市 100050
  • 收稿日期:2008-09-16 出版日期:2008-10-01 发布日期:2008-10-01

Effect of Single-session Repetitive Transcranial Magnetic Stimulation on Motor Function in Parkinson's Disease

FENG Tao, WANG Yong-jun, LI Wei   

  1. The Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050,China
  • Received:2008-09-16 Published:2008-10-01 Online:2008-10-01

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被引次数

16

摘要： 目的观察单周期、低频重复经颅磁刺激(rTMS)对原发性帕金森运动障碍的作用强度和时程。方法应用两阶段交叉设计。24例原发性帕金森病患者随机分为两组。第一组先接受初级运动皮质的rTMS,1周后再接受枕叶皮质的rTMS;第二组先接受枕叶皮质的rTMS,1周后接受初级运动皮质的rTMS。刺激强度为80%运动诱发电位阈值,频率为0.5 Hz。初级运动皮质的刺激靶点中心在手部运动皮质区,每个靶点刺激脉冲数1 000个。刺激后测评统一帕金森病评分量表(UPDRS)运动分量表评分以及自评量表评分。结果两组患者治疗性rTMS后的UPDRS运动评分最大改善率分别为(34.2±7.5)%和(36.5±8.7)%,疗效时程分别为(39±12)min和(35±11)min,均分别高于对照性rTMS后的最大改善率(7.2±3.1%、7.4±3.8%)以及疗效时程,差异有统计学意义(P<0.01),治疗顺序对疗效的作用无统计学意义(P>0.05)。结论单周期、低频、80%运动诱发电位阈值强度的rTMS可以在治疗帕金森病后短时程改善运动障碍。

关键词: 重复经颅磁刺激, 帕金森病, 疗效

Abstract: Objective To evaluate the therapeutic effect of single-session repetitive transcranial magnetic stimulation(rTMS) on motor function in Parkinson's disease(PD).Methods Twenty-four PD patients were enrolled into this two-stage study with cross-over design and divided into two groups randomly.The subjects of first group underwent therapeutic rTMS(0.5 Hz,80% of resting motor threshold,1 000 pulses×2,single-session) on primary motor cortex and underwent controlled rTMS with same stimulation parameters on occipital cortex seven days later.The subjects of second group underwent controlled two sessions of rTMS in reverse sequence.The motor function was assessed by Unified Parkinson's Disease Rating Scale(UPDRS) and Visual Analogy Scales.Results The UPDRS improvement(34.2±7.5%,36.5±8.7%) of subjects after therapeutic rTMS on primary motor cortex was significant higher than that(7.2±3.1%,7.4±3.8%) after controlled rTMS on occipital cortex(P<0.01).The duration of therapeutic effect(39±12 minutes,35±11 minutes) was significant higher than that of controlled rTMS.Conclusion The single-session rTMS has therapeutic effect of short duration on motor performance in PD.

Key words: repetitive transcranial magnetic stimulation, Parkinson's disease, therapeutic effect