《中国康复理论与实践》

《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (10): 960-962.

• 临床研究 • 上一篇    下一篇

抑郁症中医辩证与前额叶及海马1H-MRS的相关性探讨

段冬梅1; 图娅2; 陈利平1; 吴整军1   

  1. 1.解放军总医院中医针灸科,北京市 100853;2.北京中医药大学针灸学院,北京市 100029
  • 收稿日期:2008-07-08 出版日期:2008-10-01 发布日期:2008-10-01

Relativity between Changes of 1H-MRS in Hippocampus and Prefrontal Lobe and the Syndrome Differentiation of Major Depression

DUAN Dong-mei, TU Ya, CHEN Li-ping, et al   

  1. The Department of Traditional Chinese Medicine, the General Hospital of PLA, Beijing 100853, China
  • Received:2008-07-08 Published:2008-10-01 Online:2008-10-01

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摘要： 目的探讨抑郁症中医辨证分型与前额叶及海马磁共振氢质子波谱(1H-MRS)变化的相关性。方法随机选取60例抑郁症患者,辨证分型为A组(痰热型)、B组(瘀血型)、C组(虚热型)、D组(寒湿型)四型,应用三维磁共振氢质子波谱(3D1H-MRS)检查,并分别与20例健康者对照,比较双侧前额叶背外侧白质和海马组织氮-乙酰天门冬氨酸(NAA)/胆碱(Cho)、NAA/肌酸(Cr)和Cho/Cr的比值。结果A、C组双侧前额叶Cho/Cr与对照组的差异有显著性意义(P<0.05);B、C、D三组双侧海马NAA/Cr与对照组的差异有显著性意义(P<0.05)。结论抑郁症患者前额叶、海马部位的相关生化物质代谢改变与不同中医证型有一定相关性。

关键词: 辨证, 磁共振波谱, 前额叶, 海马, 抑郁症

Abstract: Objective To explore the relativity between the changes of 1H magnetic resonance spectroscopy(1H-MRS) in hippocampus and prefrontal lobe and syndrome differentiation of major depression.Methods Sixty patients with major depression(MD) were divided into Group A(phlegm-heat syndrome),Group B(blood stasis syndrome),Group C(deficient fire syndrome) and Group D(cold-dampness syndrome),and other 20 normal controls were selected.The neurochemical abnormalities including the ratios of N-acetylaspartate(NAA)/choline(Cho),NAA/creatine(Cr) and Cho/Cr were measured with three-dimension 1H proton magnetic resonance spectroscopy(3D1H-MRS).Results The ratios of Cho/Cr in white matter of the prefrontal lobe were significant higher in MD patients than that in normal controls(P<0.05);the ratios of NAA/Cr in hippocampus were significant higher in MD patients than that in normal controls(P<0.05).Conclusion There might be the relativity between the neurochemical abnormalities in hippocampus and prefrontal lobe and traditional Chinese medicine syndrome differentiation of major depression.

Key words: syndrome differentiation, magnetic resonance spectroscopy, prefrontal lobe, hippocampus, depression