《中国康复理论与实践》

《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (11): 1074-1075.

• 临床研究 • 上一篇    下一篇

甲氨喋呤干预可疑类风湿关节炎患者的疗效观察

杨磊; 朱铁锤   

  1. 新乡医学院一附院肾病风湿免疫科,河南卫辉市 453100
  • 收稿日期:2008-09-02 出版日期:2008-11-01 发布日期:2008-11-01

Effect of Methotrexate on Probable Rheumatoid Arthritis

YANG Lei, ZHUTie-chui   

  1. Departmentof Nephrology, the first Affiliated Hospital, Xinxiang Medical College, Weihui 453100, Henan, China
  • Received:2008-09-02 Published:2008-11-01 Online:2008-11-01

PDF (PC)

摘要： 目的观察甲氨喋呤干预可疑类风湿关节炎的治疗效果。方法62例可疑类风湿关节炎(RA)患者随机分成两组,治疗组32例予甲氨喋呤联合非甾体类抗炎药,对照组30例单纯使用非甾体类抗炎药治疗。随访2年。通过手部X线对关节损害进行评分。结果治疗组完成试验30例,2例因不耐受退出,8例发生骨侵蚀;对照组17例发生骨侵蚀。结论甲氨喋呤能有效延缓可疑RA患者发展至RA的临床过程,减轻关节破坏。

关键词: 类风湿关节炎, 甲氨喋呤

Abstract: Objective To investigate the protective effect of methotrexate on probable rheumatoid arthritis (RA) patients. Methods 62 probable rheumatoid arthritis (RA) patients were randomly divided into two groups, treatment group (32 cases) accepted methotrexate and non-steroidal anti-inflammatory drug and control group only non-steroidal anti-inflammatory drug. In the 2-year follow-up visit, patients who developed to RA would withdraw and accept normal combined medicine treatment. They were assessed with X-ray changes of the hand joints. Results 8 cases of the treatment group developed RA (2 cases withdrew because of intolerance), while 17 cases of the control group developed RA. The treatment group developed RA later than the control group, with less radiographic joints injury in 2 years. Conclusion Methotrexate can delay clinical process of the development of RA in the probable RA patients and reduce joints damage.

Key words: rheumatoid arthritis (RA), methotrexate