《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (01): 15-16.

• 专题 • 上一篇    下一篇

运动神经元病的腓肠神经病理形态和定量分析

徐敏;李存江;宋珏娴;卢岩;王敏;刘璐;笪宇威;贾建平   

  1. 首都医科大学宣武医院神经内科,北京市 100053
  • 收稿日期:2008-10-20 出版日期:2009-01-01 发布日期:2009-01-01
  • 通讯作者: 李存江

Sural Nerve Morphometrics of Motor Neuron Disease

XU Min, LI Cun-jiang, SONG Jue-xian, et al   

  1. Department of Neurology, Capital Medical University Xuanwu Hospital, Beijing 100053, China
  • Received:2008-10-20 Published:2009-01-01 Online:2009-01-01

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摘要： 目的 探讨运动神经元病（MND）的腓肠神经活检病理改变。方法 对22例肌萎缩侧索硬化患者进行腓肠神经活检，并采集横断面病理图像，进行定量形态学分析。结果 腓肠神经可见有髓纤维密度减低，以大纤维减少为主，薄髓纤维增多。结论 MND患者的感觉神经病理形态学存在异常。

关键词: 运动神经元病, 腓肠神经, 神经病变, 病理

Abstract: Objective To investigate the pathological features of sural nerve biopsy in patients with motor neuron disease （MND）. Methods 22 patients with amyotrophic lateral sclerosis (ALS) underwent sural nerve biopsy and routine electrophysiological examination. The transected images were captured and morphometrically analyzed.Results The myelinated fiber density decreased in ALS patients' sural nerves, and larger fibers were involved mostly. The thinly myelinated fibers increased. Conclusion The sural nerves of ALS patients shows mild but definite pathological changes.

Key words: motor neuron disease, sural nerve, neuropathy, pathology